Thanks for the input. Am thinking right now I need to get the data to determine if I have masto or mca.
Here's a good link that talks about the two.
http://stoppotsvirginia.blogspot.com/2012/07/find-your-pots-cause-wide-world-of-...I have bone pain, and issues that aren't going to be helped by anti-histimines, and I'm not sure if the nausea I'm experiencing is due to mast cell issues or pots?
I've read about Tramadol helping pots issues, and don't understand the mechanism, as pots is not really a 'pain' issue. People who are using it for pots are not using it for pain, but there's some mechanism that helps. I've also read about Tramadol being used for mca and masto. Does anyone know anything about it, or is just used for pain?
My biggest issue is sleep, and as I've mentioned it's not helped by sleeping pills or any other pills I'm aware of. My understanding is that the sleep disturbance is due to the high adrenaline, due to hyperadrenergic pots...Adrenaline is produced by the adrenal glands, so still don't quite see how any of that can be quieted by anthistamines.
Gail the explanation you gave about histamines at night was helpful, and that Clonodine helps that. Do you have a link to this data that Vanderbuilt has published? Am very familiar with the work of Dr. Raj there, and the work of the Mayo doctors, (Have you seen their brand new paper on pots?) Outstanding. As well as Dr. B Grubb's papers. Have not seen anything from Vandy about Clonodine having this impact on Neuropeptide Y, though I keep reading about Neuropeptide Y, and see it in the 'loop' when I look at mast cell diagrams.
So am hoping the mast cell doctor can do explicit testing and clear up a few things. Have most people on the forum gone to a mast cell specialist? Do you feel it helped?
Sounds like I bought Allegra last month thinking it was an H2 blocker, (to add to Zyrtec) realize now that I need to add Zantac to the mix! Thank you for clearing that up. Maybe if I get that combination right, I'll do better!
Thanks again. Good luck to Blueskies. Hope you get good results.