you ask simple questions i should have the answers all i can say is before zometa i had a lot of pain arthritis carpel tunal  sciatica bone pain back pain neve pain  and all of that went away Now the zometa is wearing off all the pain things are coming back not as bad yet the logic is if the zometa treated the courses of increasing tryptase is why my immune system carmed down So what happens if we loose the ability to know right from wrong so the answer to your question Not my JOB ITS YOURS