Any ideas of what would be coursing the chronic increasing Tryptase no reaction s

I would think the Zometa would be up to the doctor to try again.  Do you think it helped lower your tryptase?  Pain can be a symptom of reacting.

Tryptase is released as part of mast cell activation, so your mast cells are degranulating if the tryptase is elevated, from my understanding.  It can also indicate an increase in mast cells, so you could be tested for that.  I can't imagine that higher tryptase would cause lower blood pressure directly, but mast cell degranulation can cause blood pressure to fall.  Mine can go down to 80/50 if I'm really degranulating a lot.

Have you ever tried turmeric capsules?  It reduces inflammation and can help with pain.  Nancy Gould recommended a teaspoon 3 or more times/week.  You might ask your doctor if that would be contraindicated for any reason (It contains salicylates, so not for the aspirin sensitive people).  Taking it with some kind of oil or fat and with bromeliad (digestive enzyme) can help absorption.  It might also stabilize tryptase, but don't know yet for sure.

Some people ind that increased antihistamines make pain go away.  That happened for me when I reached a therapeutic dose of them.  Are you taking any H1 or H2 antihistamines?

Those are my only thoughts….

Can we have surgery while tryptase is increasing
Iam having my teeth out by surgery or should  wate until it's stable
I wouldn't be asking only my doc was unsure

Thanks Joan we don't have mast cell doctors in Australia all the specialist I have seen think systemic mastocytosis and mast cell activation is a Mif
Thay give the treatment but that's it
Until your experts are able to explain what SM with MCAS is that won't change
I am not able to go back on zometa until I have my teeth out
But I am not able to have my teeth out because I've been on zometa
Catch 22
I gess we will see what the natural process is

Ha joan  any idea why Zometa would Stop my systemic mastocytosis
And bring my Tryptase down all symptoms gone while iam on it
And why Would this not work for others with SM will increasing Tryptase

Ha Joan I tried email the experts the only reply was from Dr Kansas that's not sepllt right but you know who I mean
Iam having my teeth out as I think it maybe my teeth coursing the MCA
If that stops the increasing Tryptase then I won't need the Zometa as it is the MCA that is coursing the bone loss like cycle One thing course another

Jut having trouble getting surgery or a doctor who will do it we are going to take One tooth out first to see if it heels ok if it dose then we take the rest wish me luck
Iam confident it will work

well it turns out iam allergic to cancer or the spred of a skin cancer to the bone marrow thats why the tryptase went up and why the zometa worked