Results Summary - Last Known Values
Hi,  I tried to write these in quickly while my baby was calm, but since I started and am almost finished he's having a fit, so I'm trying to write in a note at the top quickly, so sorry if it doesn't make sense.  I don't know why it didn't mention my prostaglandins d2 which Dr. Castells told me were high (or maybe I didn't recognize the abbreviation?)  I didn't see the tryptase?  Histamines?  She only did the labs once, no bone marrow biopsy though my husband asked if we could to figure out if it was SM or MCAD, did pgd2 again not during a flare, and she told me numbers were better.  I tried to take out anything that I didn't think was relevant to make the list shorter (my cholesterol was high, that kind of thing).  I look forward to any insight into what these mean.  Some of them I think were done at my regular docs, but anyway, would love to find out if my histamines and tryptase levels are in there, am I missing them?  Thank you so much!!!

Test Name      Result      Units      Reference Range      Date
Sodium      141      MMOL/L      136-145      12/21/2010
Potassium      4.0      MMOL/L      3.5-5.2      12/21/2010
Chloride      107      MMOL/L      99-109      12/21/2010
Carbon Dioxide      29      MMOL/L      20-31      12/21/2010
ALT (SGPT) (U/L)      52 (#)      U/L      10-49      12/21/2010
AST (SGOT)      25      U/L      6-40      12/21/2010
Alk Phos      87      U/L      27-129      12/21/2010
Bilirubin (Total)      0.2 (#)      MG/DL      0.3-1.2      12/21/2010
Bilirubin (Direct)      0.0      MG/DL      0.0-0.4      12/21/2010
Total Protein      7.6      G/DL      5.7-8.2      12/21/2010
Albumin      4.8      G/DL      3.5-4.8      12/21/2010
CK      105      U/L      33-211      12/21/2010
CK-MB      < 0.2      ng/ml      <5.1      12/21/2010
Cholesterol      241 (#)      mg/dL      140-200      12/21/2010
Triglycerides      258 (#)
Normal: < 150 mg/dl Borderline [1]      MG/DL      < 150      12/14/2010
HDL Cholesterol      67
High Risk Factor for Heart Disease: Female: [2]      MG/DL            12/14/2010
LDL Cholesterol      138 (#)
ATP III Classification of LDL Cholesterol [3]      MG/DL      <130      12/14/2010
Iron      44 (#)      UG/DL      50-170      12/14/2010
Vitamin B12      401      pg/ml      211-911      04/01/2009
Folate      > 24.0      ng/mL      >5.3      04/01/2009
Amylase      61      U/L      30-118      12/21/2010
BUN      12      MG/DL      9-23      12/21/2010
Calcium      10.2      MG/DL      8.7-10.4      12/21/2010
Creatinine      0.7      MG/DL      0.5-1.3      12/21/2010
Glucose      122 (#)      MG/DL      74-106      12/21/2010
Lipase (U/L)      30      U/L      6-51      12/21/2010
Phosphorus      3.2      MG/DL      2.7-4.5      12/14/2010
Uric acid      2.6 (#)      MG/DL      3.1-7.8      12/14/2010
TSH      1.013      UU/ML      0.550-4.780      12/14/2010
TPO Ab      7.2      IU/mL      0.0-33.0      12/03/2009
HCG, urine      NEGATIVE
Caution should be used when interpreting [4]            NEGATIVE      12/21/2010
FSH      3.1 (#)
Follicular Phase: 2.5 - 10.2 mIU/ML  [5]      MIU/ML            10/05/2007
LH      8.1
Follicular Phase: 1.9 - 12.5 MIU/ML Midcycle [6]      mIU/ml            10/05/2007
Prolactin      11.9
Non pregnant: 2.8 - 29.2 ng/ml Pregnant: [7]      NG/ML            12/14/2010
Testosterone (ng/dL)      14
Please note change in reporting for "Testosterone, [8]      ng/dL      8-60      10/10/2007
Testosterone (Free)      0.3      ng/dL      0.3-1.9      10/10/2007
Progesterone (ng/mL)      58.34
Non-Pregnant: Follicular Phase: 0.15 - 1.4 [9]      ng/ml      See Comment      04/07/2009
Estradiol (pg/mL)      30
Estradiol,serum pg/ml Follicular Phase 11-165  [10]      pg/ml      see table      10/10/2007
DHEAS (ug/dL)      24 (#)
Test Performed by: Mayo Medical Laboratories [11]      ug/dL      31-228      10/06/2007
Total Volume, ur      5000      mL      600-1600      09/21/2010
Creatinine, urine      12.5      MG/DL            09/14/2009
Total Protein, unspec urine      1.0      MG/DL      0-14      09/14/2009
WBC      10.9      K3/UL      4.0-11.0      12/21/2010
HCT      40.4      %      34.9-44.5      
Hgb      13.7      gm/dl      12.0-15.5      12/21/2010
IgA      130      mg/dL      70-400      12/03/2009
IgG      1130      mg/dL      700-1600      12/03/2009
IgM      129      mg/dL      40-230      12/03/2009
Iron      44 (#)      UG/DL      50-170      12/14/2010
Ketones - UA      NEGATIVE      MG/DL      NEGATIVE      12/21/2010
LH      8.1
Follicular Phase: 1.9 - 12.5 MIU/ML Midcycle [6]      mIU/ml            10/05/2007
Lipase (U/L)      30      U/L      6-51      12/21/2010
Lupus anticoagulant (screen)      NEGATIVE                  05/11/1998
Lymph#      2.67      K3/UL      1.0-4.8      12/21/2010
Lymph# (auto)      2.08      K/uL      0.8-4.1      12/03/2009
Lymphs      25      %      15-45      12/21/2010
Lymphs (auto)      21.4      %      18-41      12/03/2009
MCH      30.6      pg      27-34      12/21/2010
MCHC      33.9      g/dl      31.5-36.5      12/21/2010
MCV      90.4      FL      80-100      12/21/2010
MPV      10.2      FL      9.6-12.0      12/21/2010
Mono#      0.73      K3/UL      0.1-0.9      12/21/2010
Mono# (auto)      0.40      K/uL      .10-0.8      12/03/2009
Monos      7      %      0-15      12/21/2010
Monos (auto)      4.1      %      2.5-8.5      12/03/2009
Neutrophil #      7.07      K3/UL      1.8-7.5      12/21/2010
Neutrophil # (auto)      6.86      K/uL      1.9-7.6      12/03/2009
Neutrophils      65      %      44-75      12/21/2010
Neutrophils (auto)      70.6      %      48-76      12/03/2009
Nitrites - UA      NEGATIVE            NEGATIVE      12/21/2010
P. notatum Ab, IgE      <0.35      kU/L      0.0-0.35      12/03/2009
PLT      267      K/UL      135-400      12/21/2010
Penicillin G Ab, IgE      <0.35      kU/L      0.0-0.35      12/03/2009
Penicillin V Ab, IgE      <0.35      kU/L      0.0-0.35      12/03/2009
Phosphorus      3.2      MG/DL      2.7-4.5      12/14/2010
Potassium      4.0      MMOL/L      3.5-5.2      12/21/2010
Protein - UA      NEGATIVE      MG/DL      NEGATIVE      12/21/2010
RBC      4.47      K6/uL      3.90-5.03      12/21/2010
RBC - UA      95 (#)      /HPF      0-3      12/21/2010
RBC Morph (manual)      NORMAL                  12/21/2010
RNP Ab      0      EU/mL      0.0-20.0      05/11/1998
Rubella Ab(s)      IMMUNE
ADVIA Centaur chemiluminometric immunoassay [14]            IMMUNE      03/25/2009
SS-A(Ro) Ab      1      EU/mL      0.0-20.0      05/11/1998
SS-B(La) Ab      1      EU/mL      0.0-20.0      05/11/1998
Silver Birch Ab, IgE      <0.35      kU/L      0.0-0.35      12/03/2009
Sodium      141      MMOL/L      136-145      12/21/2010
Specific Gravity, ur      1.005            1.000-1.035      12/21/2010
TPO Ab      7.2      IU/mL      0.0-33.0      12/03/2009
TSH      1.013      UU/ML      0.550-4.780      12/14/2010
Testosterone (Free)      0.3      ng/dL      0.3-1.9      10/10/2007
Testosterone (ng/dL)      14
Please note change in reporting for "Testosterone, [8]      ng/dL      8-60      10/10/2007
Timothy Grass Ab, IgE      <0.35      kU/L      0.0-0.35      12/03/2009
Total Protein      7.6      G/DL      5.7-8.2      12/21/2010
Total Protein, unspec urine      1.0      MG/DL      0-14      09/14/2009
Total Protein/CRE, urine      0.08
RATIOS <0.2 REFLECT INSIGNIFICANT PROTEIN [16]            < 0.2      09/14/2009
Total Volume, ur      5000      mL      600-1600      09/21/2010
Uric acid      2.6 (#)      MG/DL      3.1-7.8      12/14/2010
Urobilinogen - UA      NORMAL      MG/DL      NORMAL      12/21/2010
Vitamin B12      401      pg/ml      211-911      04/01/2009
WBC      10.9      K3/UL      4.0-11.0      12/21/2010
WBC - UA      1      /HFP      0-4      12/21/2010
WBC Screen - UA      TRACE (#)
A urine culture has been added to [12]            NEGATIVE      12/21/2010
dsDNA Ab      4      IU      0.0-25      05/11/1998
pH - UA      6.0            5.0-8.0      12/21/2010

Hiya


Your HB is a little low .
Your sodium on the high side ( not out of limits ) . This suggests to me you may be alittle dehydrated in real terms . You uria is running a little low . This is a sign of lots of weeing . Either due to the high sugar or - if its the case - high prostoglandins as they open the blood vessels in the kidneys so lots of weeing is the outcome .

Either way this is likely your cause of dehydration .

What was happening when those bloods were taken ?  

Your cholesterol is high , that is common in mast cell problems . The cardiac risk cholesterol is 67 . which could be a little lower .

Your main high is triglycerides . This is cholseterol from carbohydrate , not fat .
Your sugar is also high ( but not off the scale ) . In this context i suspect polycystic overian syndrome , leading to insulin resistance / undiagnosed type 2 diabetes mellitus ( sugar diabetes ) which will raise triglcerides and if you are very thirsty and peeing loads  

Control of PCOS / diabetes will bring down triglcerides .

Are you on a progesterone only pill / implant ????? or were these taken in the last 2 weeks of your cycle ???

Your liver blood ALT is slightly raised , BUT your bilirubin and albumin are in normal limits . So the liver is struggling a little but is very unlikly to have overt damage . This also fits with early diabetes as sugar level is controlled from the liver .

A fasting test for diabetes would be wise and advice from an endocrinologist about insulin resistance and triglcerides will help decide direction .

Allergy wise . All your IGE rast tests for those allergens were within normal limits . On all tests quoting IGE level less than 0.35 .  As are your other immunoglobulins .

Your pancreas tests are in normal limits . So you definately do not have pancritis ( inflammation of the pancreas  ).

thats my best I hope this helps . i would value heathers interpretation of what I have said . I am a very experienced RN , but always value another opinion

Josie

I wasn't fasting, but I did notice the star next to glucose.  I just found other labs that are from the allergy clinic, but are not as clear (reference range missing on most) but am hoping that this makes some more sense!:  (I think these might all be from the 24 urine collection?)
Anion 13 (*)
PGDG2: 306 ng/24 hr [2] ref range: 100-280 ng/24 hr
Tryp Mature Tryptase: <1 [1]
[1] result comment: total tryptase: 4.2
(says after that: references ranges - mature tryptase: ,1 ng/mL, total tryptase: 1-15 ng/mL
[1] HISTCRE 211 [2]
Thanks so much, this is so confusing!

The low tryptase pretty much rules out systemic mastocytosis, but it doesn't rule out a secondary disorder of mast cell activation (which can be just as disabling).  What kind of symptoms have you been having?  Unfortunately, the list of things that can mimic a mast cell disorder is quite long!  Here's a list that I've condensed from a new book edited by Dr. Castells:

Quote:


Labs are just one part of the puzzle... an accurate assessment of symptoms is equally important!  If you can tell us more about your situation we can probably help you cross some things off this list.

Heather

Hi Heather ,

I should have backed up my comment regarding cholesterol . My statement was too general .

I have started a thread on cholesterol as I have read some interesting stuff .

Bobbi ,
I hope I did not confuse matters heather is right that blood work is only one part of the picture . As on paper I have a normal tryptase and my histamine and PG2 have not been checked ( not seen as valid tests in my current medical teams view . I ahve a raiser ESR and CRP and have done since this began . My cholseterol remains high. My triglcerides are improving
Everything else is normal . My compliment 3 is raised and my IGE is 188 , but I only have minor allergies to cats , house dust and grass . I have had full patch testing ,rast testing and cpmpliment testing not in a reaction . My typtase is around 3 , no higher in a reaction ( so far )

I held onto my bloods as a hope of finding an answer , my answer is not here .

My diagnosis is angiodeama . The source of which remains elusive . I dont have heridatory angiodeama type 1 or 2 . 3 is un proveable . i dont have thyroid , adrenal or lupus autoimmunity . I currently have no blood " proof " of histamine either .

However , I have daily flushing , swelling , abdo swelling , cramps and loose stools through strong pain killers . Shortness of breath and wheeziness , nasal congestion , migraines , ringing ears , grainy eyes ,  blleding out of cycle and from my bottom with no cause ( gyne and surgery done their work up )

In shock I have quick swelling , flushing , itching eveywhere inc down below , swelling of face , tounge and laranx , itchy where I cant get to it . This compromises my airway and my blood pressure will drop sometimes it recovers , others it doesn't .

I have had the conditions excluded which make epi pens a NO .

So I use my epi pen with effect . Sometime I need 2 and everything the paramedics have to offer .

So I am happy I have a diagnosis but the major thing for me has been treatment by doctors who can see whats happening and treat it if they do not know why .

So , instead of my long list of symptoms I am a little flushed ( just had pirtion) as my singulair is just in  . This will settle me . I have hormones and pollen in my mix today .

When I first found this forum I was desperate with a capital D . I was in bed barely transfering to a commode by my bed . This place has given me a chance to really say how I feel and its been vital to me

Brain fog , was and is still a problem for me . But I am now on the right meds to help me  The thing I hated is not feeling myself . I could cope with the bodily symptoms but my mind , feeling like it was going , is horrid . Now I know its my symptom , not me . that helps so much . Although it is still irritating that i struggle to remember what I am watching in the ad break .

many hugs
Josie