Mast Cell Disorders Forum | |
http://mastcelldisorders.wallack.us/yabb/YaBB.pl
Welcome! >> Introduce Yourself/Share Your Story >> Labs & needing help with interpretation http://mastcelldisorders.wallack.us/yabb/YaBB.pl?num=1300372319 Message started by Bobbi on 03/17/11 at 03:31:59 |
Title: Labs & needing help with interpretation Post by Bobbi on 03/17/11 at 03:31:59 Results Summary - Last Known Values Hi, I tried to write these in quickly while my baby was calm, but since I started and am almost finished he's having a fit, so I'm trying to write in a note at the top quickly, so sorry if it doesn't make sense. I don't know why it didn't mention my prostaglandins d2 which Dr. Castells told me were high (or maybe I didn't recognize the abbreviation?) I didn't see the tryptase? Histamines? She only did the labs once, no bone marrow biopsy though my husband asked if we could to figure out if it was SM or MCAD, did pgd2 again not during a flare, and she told me numbers were better. I tried to take out anything that I didn't think was relevant to make the list shorter (my cholesterol was high, that kind of thing). I look forward to any insight into what these mean. Some of them I think were done at my regular docs, but anyway, would love to find out if my histamines and tryptase levels are in there, am I missing them? Thank you so much!!! Test Name Result Units Reference Range Date Sodium 141 MMOL/L 136-145 12/21/2010 Potassium 4.0 MMOL/L 3.5-5.2 12/21/2010 Chloride 107 MMOL/L 99-109 12/21/2010 Carbon Dioxide 29 MMOL/L 20-31 12/21/2010 ALT (SGPT) (U/L) 52 (#) U/L 10-49 12/21/2010 AST (SGOT) 25 U/L 6-40 12/21/2010 Alk Phos 87 U/L 27-129 12/21/2010 Bilirubin (Total) 0.2 (#) MG/DL 0.3-1.2 12/21/2010 Bilirubin (Direct) 0.0 MG/DL 0.0-0.4 12/21/2010 Total Protein 7.6 G/DL 5.7-8.2 12/21/2010 Albumin 4.8 G/DL 3.5-4.8 12/21/2010 CK 105 U/L 33-211 12/21/2010 CK-MB < 0.2 ng/ml <5.1 12/21/2010 Cholesterol 241 (#) mg/dL 140-200 12/21/2010 Triglycerides 258 (#) Normal: < 150 mg/dl Borderline [1] MG/DL < 150 12/14/2010 HDL Cholesterol 67 High Risk Factor for Heart Disease: Female: [2] MG/DL 12/14/2010 LDL Cholesterol 138 (#) ATP III Classification of LDL Cholesterol [3] MG/DL <130 12/14/2010 Iron 44 (#) UG/DL 50-170 12/14/2010 Vitamin B12 401 pg/ml 211-911 04/01/2009 Folate > 24.0 ng/mL >5.3 04/01/2009 Amylase 61 U/L 30-118 12/21/2010 BUN 12 MG/DL 9-23 12/21/2010 Calcium 10.2 MG/DL 8.7-10.4 12/21/2010 Creatinine 0.7 MG/DL 0.5-1.3 12/21/2010 Glucose 122 (#) MG/DL 74-106 12/21/2010 Lipase (U/L) 30 U/L 6-51 12/21/2010 Phosphorus 3.2 MG/DL 2.7-4.5 12/14/2010 Uric acid 2.6 (#) MG/DL 3.1-7.8 12/14/2010 TSH 1.013 UU/ML 0.550-4.780 12/14/2010 TPO Ab 7.2 IU/mL 0.0-33.0 12/03/2009 HCG, urine NEGATIVE Caution should be used when interpreting [4] NEGATIVE 12/21/2010 FSH 3.1 (#) Follicular Phase: 2.5 - 10.2 mIU/ML [5] MIU/ML 10/05/2007 LH 8.1 Follicular Phase: 1.9 - 12.5 MIU/ML Midcycle [6] mIU/ml 10/05/2007 Prolactin 11.9 Non pregnant: 2.8 - 29.2 ng/ml Pregnant: [7] NG/ML 12/14/2010 Testosterone (ng/dL) 14 Please note change in reporting for "Testosterone, [8] ng/dL 8-60 10/10/2007 Testosterone (Free) 0.3 ng/dL 0.3-1.9 10/10/2007 Progesterone (ng/mL) 58.34 Non-Pregnant: Follicular Phase: 0.15 - 1.4 [9] ng/ml See Comment 04/07/2009 Estradiol (pg/mL) 30 Estradiol,serum pg/ml Follicular Phase 11-165 [10] pg/ml see table 10/10/2007 DHEAS (ug/dL) 24 (#) Test Performed by: Mayo Medical Laboratories [11] ug/dL 31-228 10/06/2007 Total Volume, ur 5000 mL 600-1600 09/21/2010 Creatinine, urine 12.5 MG/DL 09/14/2009 Total Protein, unspec urine 1.0 MG/DL 0-14 09/14/2009 WBC 10.9 K3/UL 4.0-11.0 12/21/2010 HCT 40.4 % 34.9-44.5 Hgb 13.7 gm/dl 12.0-15.5 12/21/2010 IgA 130 mg/dL 70-400 12/03/2009 IgG 1130 mg/dL 700-1600 12/03/2009 IgM 129 mg/dL 40-230 12/03/2009 Iron 44 (#) UG/DL 50-170 12/14/2010 Ketones - UA NEGATIVE MG/DL NEGATIVE 12/21/2010 LH 8.1 Follicular Phase: 1.9 - 12.5 MIU/ML Midcycle [6] mIU/ml 10/05/2007 Lipase (U/L) 30 U/L 6-51 12/21/2010 Lupus anticoagulant (screen) NEGATIVE 05/11/1998 Lymph# 2.67 K3/UL 1.0-4.8 12/21/2010 Lymph# (auto) 2.08 K/uL 0.8-4.1 12/03/2009 Lymphs 25 % 15-45 12/21/2010 Lymphs (auto) 21.4 % 18-41 12/03/2009 MCH 30.6 pg 27-34 12/21/2010 MCHC 33.9 g/dl 31.5-36.5 12/21/2010 MCV 90.4 FL 80-100 12/21/2010 MPV 10.2 FL 9.6-12.0 12/21/2010 Mono# 0.73 K3/UL 0.1-0.9 12/21/2010 Mono# (auto) 0.40 K/uL .10-0.8 12/03/2009 Monos 7 % 0-15 12/21/2010 Monos (auto) 4.1 % 2.5-8.5 12/03/2009 Neutrophil # 7.07 K3/UL 1.8-7.5 12/21/2010 Neutrophil # (auto) 6.86 K/uL 1.9-7.6 12/03/2009 Neutrophils 65 % 44-75 12/21/2010 Neutrophils (auto) 70.6 % 48-76 12/03/2009 Nitrites - UA NEGATIVE NEGATIVE 12/21/2010 P. notatum Ab, IgE <0.35 kU/L 0.0-0.35 12/03/2009 PLT 267 K/UL 135-400 12/21/2010 Penicillin G Ab, IgE <0.35 kU/L 0.0-0.35 12/03/2009 Penicillin V Ab, IgE <0.35 kU/L 0.0-0.35 12/03/2009 Phosphorus 3.2 MG/DL 2.7-4.5 12/14/2010 Potassium 4.0 MMOL/L 3.5-5.2 12/21/2010 Protein - UA NEGATIVE MG/DL NEGATIVE 12/21/2010 RBC 4.47 K6/uL 3.90-5.03 12/21/2010 RBC - UA 95 (#) /HPF 0-3 12/21/2010 RBC Morph (manual) NORMAL 12/21/2010 RNP Ab 0 EU/mL 0.0-20.0 05/11/1998 Rubella Ab(s) IMMUNE ADVIA Centaur chemiluminometric immunoassay [14] IMMUNE 03/25/2009 SS-A(Ro) Ab 1 EU/mL 0.0-20.0 05/11/1998 SS-B(La) Ab 1 EU/mL 0.0-20.0 05/11/1998 Silver Birch Ab, IgE <0.35 kU/L 0.0-0.35 12/03/2009 Sodium 141 MMOL/L 136-145 12/21/2010 Specific Gravity, ur 1.005 1.000-1.035 12/21/2010 TPO Ab 7.2 IU/mL 0.0-33.0 12/03/2009 TSH 1.013 UU/ML 0.550-4.780 12/14/2010 Testosterone (Free) 0.3 ng/dL 0.3-1.9 10/10/2007 Testosterone (ng/dL) 14 Please note change in reporting for "Testosterone, [8] ng/dL 8-60 10/10/2007 Timothy Grass Ab, IgE <0.35 kU/L 0.0-0.35 12/03/2009 Total Protein 7.6 G/DL 5.7-8.2 12/21/2010 Total Protein, unspec urine 1.0 MG/DL 0-14 09/14/2009 Total Protein/CRE, urine 0.08 RATIOS <0.2 REFLECT INSIGNIFICANT PROTEIN [16] < 0.2 09/14/2009 Total Volume, ur 5000 mL 600-1600 09/21/2010 Uric acid 2.6 (#) MG/DL 3.1-7.8 12/14/2010 Urobilinogen - UA NORMAL MG/DL NORMAL 12/21/2010 Vitamin B12 401 pg/ml 211-911 04/01/2009 WBC 10.9 K3/UL 4.0-11.0 12/21/2010 WBC - UA 1 /HFP 0-4 12/21/2010 WBC Screen - UA TRACE (#) A urine culture has been added to [12] NEGATIVE 12/21/2010 dsDNA Ab 4 IU 0.0-25 05/11/1998 pH - UA 6.0 5.0-8.0 12/21/2010 |
Title: Re: Labs & needing help with interpretation Post by missybean on 03/17/11 at 06:22:58 Wow, you had a lot of labs! That's good though. Did they tell you your iron is low and it looks like you might be pre-diabetic/insulin restistance? Unless you weren't fasting for that draw. Melissa |
Title: Re: Labs & needing help with interpretation Post by Josie on 03/17/11 at 09:39:57 Hiya :-) Your HB is a little low . Your sodium on the high side ( not out of limits ) . This suggests to me you may be alittle dehydrated in real terms . You uria is running a little low . This is a sign of lots of weeing . Either due to the high sugar or - if its the case - high prostoglandins as they open the blood vessels in the kidneys so lots of weeing is the outcome . Either way this is likely your cause of dehydration . What was happening when those bloods were taken ? Your cholesterol is high , that is common in mast cell problems . The cardiac risk cholesterol is 67 . which could be a little lower . Your main high is triglycerides . This is cholseterol from carbohydrate , not fat . Your sugar is also high ( but not off the scale ) . In this context i suspect polycystic overian syndrome , leading to insulin resistance / undiagnosed type 2 diabetes mellitus ( sugar diabetes ) which will raise triglcerides and if you are very thirsty and peeing loads Control of PCOS / diabetes will bring down triglcerides . Are you on a progesterone only pill / implant ????? or were these taken in the last 2 weeks of your cycle ??? Your liver blood ALT is slightly raised , BUT your bilirubin and albumin are in normal limits . So the liver is struggling a little but is very unlikly to have overt damage . This also fits with early diabetes as sugar level is controlled from the liver . A fasting test for diabetes would be wise and advice from an endocrinologist about insulin resistance and triglcerides will help decide direction . Allergy wise . All your IGE rast tests for those allergens were within normal limits . On all tests quoting IGE level less than 0.35 . As are your other immunoglobulins . Your pancreas tests are in normal limits . So you definately do not have pancritis ( inflammation of the pancreas ). thats my best :-) I hope this helps . i would value heathers interpretation of what I have said . I am a very experienced RN , but always value another opinion :-) Josie |
Title: Re: Labs & needing help with interpretation Post by Starflower on 03/17/11 at 12:08:43 wrote on 03/17/11 at 09:39:57:
Careful there with the generalizations. My cholesterol is very low... 138 the last time I had it measured (in September 2010). I've never read any scientific explanation for a connection between cholesterol levels and mast cell disorders. Anyway... Hi Cydnie, Has anyone asked you to do a two-hour glucose test? I agree that your labs are consistent with diabetes or pre-diabetes. Aside from the high cholesterol, nothing else stands out to me... in fact, you seem to be in pretty good health, overall (which is good!) You don't seem to have any autoimmune issues going on (also good!). None of these tests rule a mast cell disorder in or out. Here's a link that shows the kinds of tests you would need. http://mastcelldisorders.wallack.us/yabb/YaBB.pl?num=1296696091 By the way... I don't think you've told us your "story" yet. What brings you to our website? Heather |
Title: Re: Labs & needing help with interpretation Post by Bobbi on 03/17/11 at 13:02:15 I wasn't fasting, but I did notice the star next to glucose. I just found other labs that are from the allergy clinic, but are not as clear (reference range missing on most) but am hoping that this makes some more sense!: (I think these might all be from the 24 urine collection?) Anion 13 (*) PGDG2: 306 ng/24 hr [2] ref range: 100-280 ng/24 hr Tryp Mature Tryptase: <1 [1] [1] result comment: total tryptase: 4.2 (says after that: references ranges - mature tryptase: ,1 ng/mL, total tryptase: 1-15 ng/mL [1] HISTCRE 211 [2] Thanks so much, this is so confusing! |
Title: Re: Labs & needing help with interpretation Post by Bobbi on 03/17/11 at 13:33:20 You're right, I don't think I did. I thought I shared it before the site moved, but I think it was sort of mixed in with someone else's story. Anyway, Dr. Castells called it an MCAD, she thought started from progesterone during my many attempts to get pregnant, and the many hormones the doctors prescribed. Anyway, the biggest thing she noticed, she told us (which I didn't add until a few minutes ago - it wasn't with the other labs) was a high prostaglandin level. I was happy someone finally understood, and she was telling me she could help me to get rid of it entirely. It began 2 1/2 years ago with goosebumps, intense burning of my skin, swelling behind my knees, flushing red all over my legs that would become mottled, then some areas would be cold, some hot, pricking sensations, just utter pain like I've never felt, and I've had some intense pain in my life. I thought maybe it was fibromyalgia (one of my sister's has this), one doctor told me when I was 10 weeks pregnant it could be MS (that shot my stress levels way high, I was terrified after watching my friend's mom fall apart, that was my only experience seeing MS) and went to neurologist after neurologist. Finally a rheumy sent me to Castells (took so long for the appointment, I already had the baby when I went to see her). She started me on an aspirin regimen and told me that would lower the prostaglandins back to normal, and then all would be fine, and it would be over! I was so excited, and thought I would be pain free for the first time in my life. But things have gotten worse. I've suffered migraines my whole life, as well as tacchycardia and abnormal rhythms, but recently that's all gotten worse, intense migraines, as well as the skin pain getting worse and worse. I couldn't tell whether or not she had checked the other things that I needed to do, but she was absolutely against a bone marrow biopsy to determine whether or not it was SM or an MCAD. But I just looked at the labs suggested and in step 1, if you don't have an abnormal tryptase, you don't need one? I was going to have a tilt table test done, Dr. Castells wanted me to have that before going back to her. Anyway, I do notice when I don't take my gastrocrom, zantac and claritin, I'm a lot lot worse. I can get worse pretty fast if I go without them for 2 days or so. Anyway, I'm baffled really. I've had fasting glucose done before (and when I was pregnant) and it was fine. But the cardiologist wants me to do a fasting cholesterol (haven't done that yet either) so maybe I can do both. Other than the pgd2, are the tryptase levels normal, does anyone know? Or any other suggestions? (I'm also taking iron supplements now, so hopefully that's better!) Thanks so so much everyone! Cyd |
Title: Re: Labs & needing help with interpretation Post by Starflower on 03/17/11 at 13:33:37 The low tryptase pretty much rules out systemic mastocytosis, but it doesn't rule out a secondary disorder of mast cell activation (which can be just as disabling). What kind of symptoms have you been having? Unfortunately, the list of things that can mimic a mast cell disorder is quite long! Here's a list that I've condensed from a new book edited by Dr. Castells: Quote:
Labs are just one part of the puzzle... an accurate assessment of symptoms is equally important! If you can tell us more about your situation we can probably help you cross some things off this list. Heather |
Title: Re: Labs & needing help with interpretation Post by Starflower on 03/17/11 at 13:41:55 Bobbi wrote on 03/17/11 at 13:33:20:
Yes, 4.2 is totally normal. Mine is very similar... that hasn't stopped me from going into anaphylaxis. I feel better now on a mixture of H1/H2 antihistamines, Gastrocrom, and Singulair. I wouldn't dare stop taking them! Even on high doses of antihistamines I still get breakthrough symptoms like heartburn, nausea, headaches, hives, etc... Nothing I can't live with. It sounds like you're on the right track though. Have you tried any lifestyle changes like the low-histamine diet, trigger avoidance, reducing your stress levels, etc...? These are just as important as any medication! You'll find lots of ideas as you wade through our website. BTW... welcome to the group ;) Heather |
Title: Re: Labs & needing help with interpretation Post by Josie on 03/18/11 at 05:50:55 Hi Heather , I should have backed up my comment :-) regarding cholesterol . My statement was too general . I have started a thread on cholesterol as I have read some interesting stuff . :-) Bobbi , I hope I did not confuse matters ;-) heather is right that blood work is only one part of the picture . As on paper I have a normal tryptase and my histamine and PG2 have not been checked ( not seen as valid tests in my current medical teams view . I ahve a raiser ESR and CRP and have done since this began . My cholseterol remains high. My triglcerides are improving :-) Everything else is normal . My compliment 3 is raised and my IGE is 188 , but I only have minor allergies to cats , house dust and grass . I have had full patch testing ,rast testing and cpmpliment testing not in a reaction . My typtase is around 3 , no higher in a reaction ( so far ) I held onto my bloods as a hope of finding an answer , my answer is not here . My diagnosis is angiodeama . The source of which remains elusive . I dont have heridatory angiodeama type 1 or 2 . 3 is un proveable . i dont have thyroid , adrenal or lupus autoimmunity . I currently have no blood " proof " of histamine either . However , I have daily flushing , swelling , abdo swelling , cramps and loose stools through strong pain killers . Shortness of breath and wheeziness , nasal congestion , migraines , ringing ears , grainy eyes , blleding out of cycle and from my bottom with no cause ( gyne and surgery done their work up ) In shock I have quick swelling , flushing , itching eveywhere inc down below , swelling of face , tounge and laranx , itchy where I cant get to it . This compromises my airway and my blood pressure will drop sometimes it recovers , others it doesn't . I have had the conditions excluded which make epi pens a NO . So I use my epi pen with effect . Sometime I need 2 and everything the paramedics have to offer . So I am happy I have a diagnosis but the major thing for me has been treatment by doctors who can see whats happening and treat it if they do not know why . So , instead of my long list of symptoms I am a little flushed ( just had pirtion) as my singulair is just in . This will settle me . I have hormones and pollen in my mix today . When I first found this forum I was desperate with a capital D . I was in bed barely transfering to a commode by my bed . This place has given me a chance to really say how I feel and its been vital to me ;-) Brain fog , was and is still a problem for me . But I am now on the right meds to help me :-) The thing I hated is not feeling myself . I could cope with the bodily symptoms but my mind , feeling like it was going , is horrid . Now I know its my symptom , not me . that helps so much . Although it is still irritating that i struggle to remember what I am watching in the ad break . many hugs Josie |
Mast Cell Disorders Forum » Powered by YaBB 2.3.1! YaBB © 2000-2009. All Rights Reserved. |