I received my first Xolair injection this past Thursday (today is Sunday). I met with a PA who reviewed my history and the Xolair process with me. She mentioned a couple of times that I am not to self-reduce my medicines for four months. I kept telling her I wouldn't. They sent me back to the waiting room while they mixed my Xolair, which would take 20 minutes.
Another person called me into the shot room. She, too, reviewed what she was going to do and also kept telling me not to self-reduce my current medicines. I also had to initial a paper agreeing to that and what I understand, etc. No problem.
I received two skinny-needled injections, one in the back of each arm. Boy did I breathe a sigh of relief because I'm a weenie when it comes to needles! I took a deep breath and braced myself for the worse and then felt silly because I barely felt them. It's because the needles are so thin and probably very short. No more fear for me. Whew!

Two 150 mg of Xolair are to be given every four weeks. The first four rounds require me to sit in the waiting room for two hours. After that, I will only have to wait 30 minutes after each shot. I must carry my two Auvi-Q injections with me at all times.
This doctor's office charges $2,800 for the pair of shots. Genetech will help patients with their co-pay provided their total income is under $100,000 USD per year. Patients who are on Medicaid, Medicare, or TriCare insurance, even if income is under their current level, do NOT qualify for assistance.
Reactions? Previous shots for flu and shingles created huge red, swollen, hot welts alongside my entire arms to my elbow. Miserable. I noticed a headache developing, no pain in either arm. When I awakened, the first thing I did was touch my arms to realize that I felt no pain. Then I got up and checked my arms in the mirror and they were perfect. I could not even seen anything at the injection sights.

I read that some patients had a headache that lasted two days. Mine started shortly after the shot, peaked by evening and started to decrease Friday and Saturday. By Saturday mid-morning, I would say it was gone.
I hope this information will be helpful to others!