My 24 hr urine test showed low prostaglandin levels (lower than levels) ... my platelets are low (100-125 level) and clotting time is high (takes longer than normal to clot).  My only diagnosis is anti-ige receptor AB (and hypothyroidism & asthma).  I was told that none of these should cause me to have severe reactions, swelling and hives.  Dr. is pretty much ruling out mastocytosis but still not completely sure.  The Hematologist is guessing that I have ITP because my levels have been low for several years (only coming back up once last summer).  For years wondered if I have aspirin sensitivity/triad but I do a low salicylate diet and low histamine diet.  I need a dr. who can put the pieces of this puzzle together because I have no idea what is going on but it is so scary and Ive lost too much weight.  I want to be able to eat better, too.

Hi Sasha,

I also have anti-IgE receptor antibodies and Hashimoto's... and I bleed easily (petechiae, bruises, nosebleeds, abnormal uterine bleeding) even though two hematologists couldn't find any explanation for it.  My von Willibrand's factor is on the "low side of normal" and my platelets are never very high (although I've heard/read that it's not a major concern until you dip below 50,000).  I have to be careful about supplements that are blood thinners... garlic, turmeric, fish oil, etc...  I recently had some genetic testing that said I would have "increased sensitivity" to Warfarin, which is another blood thinner.  I thought, "Tell me something I don't know."

Anyway... I've had "idiopathic anaphylaxis" and allergic reactions to quite a variety of things: latex, silicone spray, exercise, overheating, air travel, adhesives, fragrances in candles and detergent, etc... The only thing that shows up on RAST is a shrimp allergy, which is one of the least bothersome to me!  My baseline tryptase and bone marrow are "normal," so I fall into the MCAD category.

What treatments (if anything) have you tried so far?  Antihistamines keep me out of the ER, but cromolyn sodium and Singular gave me a pretty normal life back.  I also take vitamin K, which is the opposite of a blood thinner... it definitely helps.  People can suggest doctors if you want to share your location.

Heather