I've never heard of cyproheptadine, but chlorpheniramine (Chlor-Trimeton) is definitely fine.

When I get a headache, I find that the best remedy is a combination of Tyleonol (acetaminophen, paracetamol) and caffeine.  I found some tablets that combine the two without aspirin, but you could also just take Tylenol with a cup of coffee or a soda that has caffeine (which is especially nice if the cold helps you!)  The reason it works is because caffeine is a vasoconstrictor... it counteracts the vasodilation of degranulation.  Neat trick  This combination really works for me.

Heather

You couldn't exactly call me a shocker, but for me the migraines are really debilitating.  Without sumatriptan, my migraines will take me down for 2-3 days.  If I am not doing something to prevent them, I will have them 2 to 4 days a week.  That doesn't leave much of a life.  The day after I have a migraine, I am very likely to get another one the next day.  After I have one, I have to drink two large ice teas the next day to stop the cycle.  Sometimes my migraines start after an activity - like working out.  (I'm allergic to coffee.)  Sometimes they start after an allergic reaction to a food.  Headache remedies like acetaminophen don't touch the pain.  What I have learned is that my sarotonine needs to be stabolized to prevent migranes.  There are some meds that do this, but one of them made me dizzy, another one activates mast cells even more.  

I started taking Chlorpheniramine two nights ago.  It is supposed to stabalize sarotonine.  So far so good.  I thought I was going to get one earlier today, but it never came.    I am going for a long bike ride tomorrow.  That will put it to the test.

That is interesting.  I know nothing about chemical structure, but I am feeling better and better.  My hives are going away too - so it is working better than hydroxizine for rash and hives.