You're not alone in having odd reactions to meds.  Lots of us do.  I had to start gastrocrom really, really slowly, with part of a vial in a lot of water and working up over weeks.  It still bothers me occasionally, and what helps is to drink an extra glass of water.

I saw a patent application for a derivative of doxepin that is supposed to be for stabilizing mast cells in the eye, but I haven't heard of it as a systemic stabilizer.  Maybe someone else knows for sure.  Doxepin was the first medicine that helped me.  It helps people get into Stage 4 sleep, which might have stabilizing effects.  Sleep really seems to help me, and lack of it to de-stabilize everything.

I 'think' it was Dr Afrin that told me Doxepin IS a mast cell stabilizer. I take it and as for the mast cells it helped 'some'. As a sleep aide it helped tremendously!
Here is what I read online:
http://en.m.wikipedia.org/wiki/Mastocytosis#section_6
Treatment.....
Antidepressants are an important and often overlooked tool in the treatment of mastocytosis. Depression and other neurological symptoms have been noted in mastocytosis.[9][10] Some antidepressants, such as doxepin, are themselves potent antihistamines and can help relieve physical as well as cognitive symptoms.