I think the medications that help us can also make us wired, even some of the "sedating" ones do this to me. I use to need alot more sleep than I am getting now. What meds. are you taking and when?

I can't remember all the details of your history, but here are a few thoughts....

Not sleeping can be a vicious cycle and can cause you to have more symptoms.  You could ask your doctor for something to take to help you feel sleepy at night.  I do that many nights, and it does help.

It could be adrenalin from constant triggering or your anxiety over your symptoms (something I think we've all experienced) or the mediators being let loose in your system by the mast cells.

I don't see an H2 antihistamine in your list of meds, such as Zantac or Pepcid.  I don't know who your doctor is, but you might want to talk with him/her to see if one of those would help you be more stable.  Most people take 1 or 2 Zantac (150 mg.), twice a day, or 20 mg. Pepcid in addition to the H1 antihistamines.  If you're having break-through symptoms during the day, ask your doctor if you can take an extra H1 antihistamine.

The stress of all those symptoms can be a circular problem.  More symptoms cause  more stress, then more stress causes more symptoms.  Maybe a short-term anti-anxiety might help.

When you're on enough meds, you're symptoms will lessen and you'll feel up to going out.

Thanks to all!  Great ideas and things to try. I will forge ahead!