My allergy /immunologist wants me to have a bone marrow biopsy do e this week.  My platelets are still low and I have repeated reactions.  My tryptase is around 4-5 but she said it could be false it is wrong 15% of the time.  How bad was it?  Anything I should do to prepare if be aware of ?

People's experiences vary a lot.  I had only local anesthesia and an ativan and had no pain except for the local anesthetic injection.  The doctor said it's not hard to miss the major nerves.  Also, the local was injected deeply, so I think that made a difference.  And a senior hematologist did the biopsy.

Ask that it be done by someone experienced.  A pain reliever in advance might help, too.  I had very little pain after.  Felt like a bruise for a few days.

Good luck!  Hope it's painless!

BTW, I did pre-medicate with the usual antihistamines and prednisone..