Hi, I'm new to the forum. I have been having some symptoms -- angioedema, edema, (lymphedema due to surgery but not related), paradoxal reactions to medications, flushing (I think), etc. So I recently had labs done and my Total IgE was 111 and my doc sent me to an allergist. My only allergy is dust -- which is high -- but doesn't seem to warrant a high total IgE. He did more lab work, and my Tryptase was 10.8 -- well the reference number was less than 11.5 so it is considered normal. But from what I've read on your forum is may not actually really be normal? My eosinophils were also high -- although not super high. I feel like everything is just a bit off -- and nothing looks scary enough to get the doctor's attention.

I did have a very low Vitamin D count, so I am on Vitamin D supplements. Not sure if that would be related?

I have a 5 year old daughter who suffers from abdominal pain and motility issues. She was scoped and had instestinal inflammation from non-specific cause. She also had anaphylaxis to a cashew nut and had severe allergies. I asked about MAST cells being tested in her gut but they said they didn't do that. So, I wonder about her as well as myself.

Do you think a 10.8 tryptase needs to be followed up on? I haven't had angioedema in probably close to 6 months -- going gluten free seems to have helped. I do get hives when exercising in the cold -- but not recently. But, my edema -- which is much much worse in my right calf/ankle/foot really bothers me.

Thanks for your help!!

Thanks so much for getting back to me! So I do think he tested me for Hereditary Angioedema -- but I do not think it was that complement -- it was a different one? I need to find the labs (and I will post again) but that was normal. It makes me wonder though if that has a different normal like the tryptase does?

I haven't been back to my allergist since the labs so I haven't discussed the tryptase with him but I am guessing he is going to say "it is normal. or, it isn't high enough to mean anything." So then what do I say?

He did just have me start daily antihistamines -- and I am not sure they are helping? Not with the edema/swelling anyway. I am taking allegra -- is that the right one to take?

He is retesting my Vitamin D in 3 months to make sure it went back up.

So I think I might be getting somewhere with this. My allergist of course said anything under the reference range is a negative and there's no "grey area." But he's old school and I don't think he's right. So I saw my GP today and told her about all of it and she seems to agree with me. There is something allergic/mast cell related going on with me that just a dust allergy doesn't seem to explain. So, she prescribed Zantac & Singulair, to add to the Allegra my doctor already prescribed. Does that sound like the right combination? I am going to try it and see how it goes!