http://en.wikipedia.org/wiki/Histamine_H3_receptor Quote:The H3 receptor has also been shown to presynaptically inhibit the release of a number of other neurotransmitters (i.e. it acts as an inhibitory heteroreceptor) including, but probably not limited to dopamine, GABA, acetylcholine, noradrenaline, and serotonin.
http://en.wikipedia.org/wiki/H3_receptor_antagonist Quote:H3 antagonists have stimulant and nootropic effects, and are being researched as potential drugs for the treatment of neurodegenerative conditions such as Alzheimer's disease.
In other words if I understand it correctly, the H3 histamine receptor may play a very significant role in the amount of other neurotransmitters being released. More important it INHIBITS the release when histamine binds to it.
Serotonin play a very significant role when it comes to mood. People with high histamine levels may therefore experience:
- Anxiety in typically low stress situations
- Impatience without explanation
- Fatigue when you should feel rested and energized
- Cognitive impairment (inability to focus, poor memory, lack of mental clarity)
- Negative thoughts with no apparent cause
- Agitation
- Mania/obsession
- Mood swings
- Strong sugar cravings
- Chronic pain (fibromyalgia, migraines, back pain)
- Indifference to situations you typically would care deeply about
- Excessive worrying
- Inability to fall and stay asleep
- Masochism
- Moderate to overwhelming sadness
- Feeling worse and agitated during bad/dark weather
Dopamine is associated with pleasure and euphoria. People with low histamine therefore battle to experience pleasure and euphoria even though they may not necessarily feel depressed. Drug and sex addictions cause a temporary increase in dopamine and therefore the user experience pleasure and euphoria for a while. High histamine may therefore lead to addictions.
Unfortunately H3 antihistamines are still in it's infancy.
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Histamine a cause of depression, addiction & fatigue (Read 4186 times)
