Daughter started ketotifen on 8/6 and I am wondering if her worsening of psych sx's could be from that.  I just tried calling Castells office and she is out of town til Tues and we are not officialing a patient yet.  We have had phone consults is all.  Any insight??

Anything is possible. Every individual is unique in how they react to medications.

So glad she's better now!

My daughter seems to never get drowsy from meds. I am pretty sure she is having some issues making her own neurotransmitters or too much glutamate,etc..she get excitatory symptoms with B vitamins and apparently ketotifen.  My daughter was very scary mean and rageful. The interesting part is the exact same thing happened on neuroprotek this summer. I think somehow stabilizing mast cells for her creates a drop in serotonin.  She is unique. I think she has some metabolic issues we have not identified.  She is also IgE positive to everything on her RAST test except meat, fish and eggs.  IgE as high as 2200. That may not be typical for mcas.  I can't wait to see what castells says about all of this.  my daughter has migraines, psoriasis, hashimotos all implicated with mast cells.  thank you for all the support. I feel like she has to get worse to figure out the next step..ugh!

We stared ketotifen after phone consult with dr castells and then dr castells spoke to our local dr - who prescribed it.  her reaction to this was not immediate.  we started with 1 mg a day and then went to 2 mg a day.  I must say this reaction was much like neuroprotek.  It took about 2 wks to notice increase depression, anxiety and rage.  once off it was almost immediate change back to improved mood and no rage- just typical moodiness, hypoglycemia stuff, etc...

we started gastrocrom slowly from our dysautonomia dr in virginia.  she started with 1 vial before each meal.  it took a couple months before we progressed to 2 vials.  she had worsening of bloating sx's at first but we were told to hang in there.  after the first month her GERD seemed better.  she has been on this for almost 1 year.  it helped GI stuff:)