Brigitte,
Singulair, an antileukotriene, is typically an asthma med used to prevent  histamines from setting off the prostaglandin and leukotriene cascade.  Singulair stops blocks these chemicals from being released.  Patients diagnosed with asthma have mast cell issues localized in their lungs tend to tolerate Singulair.    

I too have lots of issues with meds, but I didn't have any issues with Singulair.  It may make you sleepy, so my pharmamcist suggested to take it at night with my bedtime meds.  If I don't take it, I can definitely tell.  I also take an extra one when I feel chest congestion during degranulation.  

Best wishes, Lyn  

Thanks Lyn, thanks Deborah! So singulair works on "stuff" that antihistamines don't work on???? What happens when the cascade falls? All the bad symptoms??? So this morning I woke up feeling great. One of my most dear friends got into town from Las Vegas. Before I picked her up, I asked her if she had any fragrances on. She said no. So I went to get her. As soon as she got in I got sick. I could smell the deodorant. I rolled down all the windows in the car and tried not to breath!!! Then she told me that she forgot and had put on deodorant and tried to wipe it off (we all know that doesn't work!) anyways, I was sick the rest of the day. Then the pharmacy called to say that insurance had approved my singulair and it was ready for pick up. I was hesitant to take it, but I figured I couldn't feel any worse, so I took it a little over an hour ago. I hope it's not a coinky dink, but I feel sooooooo much better! I can't believe it! I hope it's not a fluke! Does singulair make everyone feel so much better!!! OMG!   I feel a sense of calm in my body I haven't felt in a long time! What do you feel like when you don't take singulair??? BTW Deborah, after you wrote me last week to try singulair, that's when I got my doc to prescribe! So thanks for the push!

Wow! I'm still in awe! I feel like I took a Valium or something! Lol my body is always so keyed up and irritable and sick. This is crazy! Is this what normal feels like??? I can't thank you all enough! This forum is a life saver! I pray that anyone with any mast cell disorder will find this forum for support!

Ok, so last night I took my first singulair, and like I said, it kind of felt like I had taken a Valium or something. By body was so calm I couldn't believe it! When I laid down to go to bed I felt so calm too (which isn't normal for me, 80% of the time I feel like I'm going to explode!) anyways, by the middle of the night I kept waking up kind of in a weird twilight sleep and I was having weird dreams. I also noticed that I was clenching my jaw. This morning I had a slight headache, my bidy was achy,sore throat and my chest hurt like I am catching a cold. Could these be side effects from the singulair? Or maybe I am getting a cold. When I do get a virus, I usually feel this way. Maybe a coincidence?? Now, at 2pm I feel pretty relaxed again, but I have a kind of hollow empty feeling in my body. Weird. I'm thinking of maybe cutting my singulair today in half?? I am extremely sensitive to medications, I always prefer to start off in baby doses of anything. Maybe I just have to get used to the feeling of singulair! I don't know!