Depends what mast cell issue you have.  I have SM and I can't take baby aspirin, it sets off the anaphylaxis.  Masto's have to be very careful if the doc tries them on baby aspirin some can tolerate it, others can't.  Not sure though how aspirin effects these other MCAS or MCAD stuff.

Many people here are sensitive to salicylates, naturally-occurring substances that is in most plants as a natural defense and that also happen to be THE ingredient in aspirin.  I would be very careful in testing aspirin and even if you are initially able to tolerate it, if you take it every day you may eventually develop a sensitivity.  

I can't take coated adult asprin or baby asprin due to the dyes, as they make me anaphylax,so that leaves me uncoated adult asprin.  I have found Bayer to have fewer inactive ingredients.

While I don't take the adult asprin on a reuglar basis due to stomach pain and nausea, it is extremely helpful when I get one of those nagging headaches that nothing else will touch.  I avoid the stomach issues by taking a dye free Benedryl gel tab 30 minutes prior to taking the asprin.  It works everytime for me to stop the prostaglandin cascade.      

Bob:
Depends on what symtom you're working on. My doc recommends baby aspirin for flushing, but I'm nasids intolerant, so don't take it. If it's for pain. & you have trouble with tylonal, maybe it's the tablet
version that is the problem. I take liquid tylonal w/ good result. It's hard to find, in fact generic is the only way as tylonel quit producing
their cherry blast. The only problem with it is the taste, have to add something to it, it tastes so bad. But helps w/pain.
MikeV