I believe that they can, but to what extent I don't know.  Also it may be possible that only one of the two markers would be elevated but I really don't know a whole lot about these markers, however.   Yet funny thing, my biopsies showed tons of chronic inflammation but both of these markers were normal on me.  

Melissa, masto is a disease of a contradiction of terms. Mast cells are responsible and totally involved in inflammatory processes, and yet, in my case, these markers for inflammation were negative in spite of the physical proof of inflammation.   Why?  I've not a clue!  

Lisa

Hey Melissa, get this!  I spoke with an authority on this and he told me that he himself doesn't quite know what these markers mean in regards to masto!!  He said that he's seen cases where some patients have them elevated and others not and it doesn't seem to indicate much.  He said that there are those like me where there is obvious widespread inflammation going on but don't have elevated markers.  And there are others where either one or both can be elevated but there isn't much really going on to explain the elevations.  He said that he's come to ignore these markers for they don't really indicate much regarding us masto patients!!

So, dear, in other words, if they are your only really off markers and there's nothing to really reinforce it, DON'T WORRY ABOUT IT, it's probably nothing and one of those freaky contradictory things that masto does!!

Ha!  How's that for an answer?!

Hugs!

Lisa

Hey Melissa,

Wonder if it could be prostaglandins?  Can you take Tylenol?  If so, you could try the maximum dose and see if it helps.  I know it sounds like sending a boy to do a man's job, but it does have an effect on prostaglandins.  If you can tolerate aspirin, or ibuprofen, or naproxen, one of those might work better.  Dr. Theoharides sells his algonot formula with quercetin and other ingredients that reduce inflammation.  It takes some months to get the full effect.  Quercetin can also be taken alone.

A couple of times a year I have to do a burst of prednisolone.  It seems to turn down the heat (pain and inflammation) and resets something that gives me relief for a longer time.