Fish oil is also a blood thinner.  You could try it... but I think it would be a bad combination with POTS.  

Heather

I don't have POTS, just ISM.  I take fish oil every day, and have done so for quite a few years now.  I have been able to tolerate it.  I can honestly say I feel much better when I take it regularly, and it has not caused my tryptase to go up over time either.  However, I can eat regular fish without a problem too.

I have done a lot of reading on the anti-inflammatory nature of it, as my field is immunity and inflammation.  I think that there is some pretty compelling data about it, and I think more studies should be done.

I think it would depend on whether or not you are allergic to it, or any of the components in the particular preparation you are taking.  Look for a preparation that is USP certified, and one that has also been purified to get rid of any mercury (which can be found in some fish oil vitamin preps).  I only take 1200 mg once per day, not a lot.  I think you would have to take higher doses of it before you would have to worry about blood thinning.

I would talk with your doc and see what he says.  My masto docs have told me they think it would be o.k. for me as I don't react to it.  I have a lot of cardiovascular disease in my family, so I take it to help with that as well.  It will raise your total cholesterol, but that's because it is elevating the levels of your "good" cholesterol. A nice plus is that it makes your hair grow better!