European Journal of Pharmacology
Volume 602, Issues 2-3, 14 January 2009, Pages 432-438
     
     
Hi All ,

I found this article titled . In it it demonsatrates 3 statins for cholesterol which have mast cell stabilising benifits .

Fluvastatin inhibits mast cell degranulation without changing the cytoplasmic Ca2+ level
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Masanori Fujimotoa, Tatsuya Okaa, Takahisa Murataa, Masatoshi HoriCorresponding Author Contact Information, a, E-mail The Corresponding Author and Hiroshi Ozakia

aDepartment of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1-1-1Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
Received 4 March 2008;
revised 13 November 2008;
accepted 20 November 2008.
Available online 27 November 2008.

Abstract

We evaluated the pharmacological effect of statins (3-hydroxy-3-methylglutaryl-CoA reductase inhibitors) on mast cell degranulation in RBL-2H3 cells. A hydrophilic statin (pravastatin) did not inhibit degranulation induced by dinitrophenol-human serum albumin (DNP-HSA); in contrast, lipophilic statins (simvastatin, fluvastatin and atorvastatin) inhibited DNP-HSA-induced degranulation in that order.

The inhibitory effects were completely attenuated by simultaneous treatment with 100–1000 µM mevalonic acid for 4 h. We used fluvastatin to clarify the mechanism of the statin-mediated inhibitory action of mast cell degranulation.

Fluvastatin (3 µM) had no effect on Ca2+ release from the endoplasmic reticulum or Ca2+ influx in the DNP-HSA- or thapsigargin-stimulated cells.

Fluvastatin treatment also had no effect on the total granule content of the cell or sensitivity to DNP-HSA and IgE. Fluvastatin (3 µM, 24 h treatment) also failed to affect the morphology, proliferation, and viability of RBL-2H3 cells. Geranylgeranyl transferase inhibitor, GGTI-286 (20 µM), but not farnesyl transferase inhibitor, FPTIII (20 µM), inhibited the DNP-HSA-induced degranulation. The GGTI-286-induced inhibitory action was not associated with a decrease in the cytoplasmic Ca2+ level. In conclusion, fluvastatin at a lower concentration range inhibited DNP-HSA-induced degranulation without affecting the cytoplasmic Ca2+ response and also without changing the amount of granule content and proliferation of the mast cells. The statin-induced inhibitory action may be mediated by the suppression of geranylgeranyl transferase via the depletion of intracellular mevalonic acid.


I will look for work on Simvastsin as this is the top inhibitor and for those who can't tolerate corn in meds it is availble in liquid form in the UK.

Is this new information ? i will get the full article .