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Biocell. 2003 Aug;27(2):163-72.
Role of mast cells in gastrointestinal mucosal defense.
Penissi AB, Rudolph MI, Piezzi RS.
Instituto de Histología y Embriología Dr. Mario H. Burgos (IHEM-CONICET),
Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Casilla de Correo 56,
(5500) Mendoza, Argentina. apenissi@fcm.uncu.edu.ar
The purpose of this review, based on studies from our laboratory as well as from
others, is to summarize salient features of mast cell immunobiology and to
describe their associations with gastrointestinal mucosal defense.
Gastrointestinal mast cells are involved in many pathologic effects, such as food
hypersensitivity. On the other hand, they also play a protective role in defense
against parasitic and microbial infections. Thus, they have both positive and
negative effects, but presently the mechanisms that control the balance of these
various effects are poorly known. It has been suggested that stabilization of
mast cells may be a key mechanism to protect the gastrointestinal tract from
injury. Few molecules are known to possess both mast cell stabilizing and
gastrointestinal cytoprotective activity. These include zinc compounds, sodium
cromoglycate, FPL 52694, ketotifen, aloe vera, certain flavonoids such as
quercetin, some sulfated proteoglycans such as chondroitin sulfate and
dehydroleucodine. Dehydroleucodine, a sesquiterpene lactone isolated from
Artemisia douglasiana Besser, exhibits anti-inflammatory and gastrointestinal
cytoprotective action. The lactone stimulates mucus production, and inhibits
histamine and serotonin release from intestinal mast cells. The lactone could act
as a selective mast cell stabilizer by releasing cytoprotective factors and
inhibiting pro-inflammatory mast cell mediators.
PMID: 14510234 [PubMed - indexed for MEDLINE]
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Role of mast cells in gastrointestinal mucosal defense. (Read 1281 times)
