Identification of a Neuronal Receptor Controlling
Anaphylaxis

Previously, anaphylaxis has been regarded as a result of an
over-active or defective immune system. We now present data
suggesting that dysfunctional regulation of primary afferents
can cause anaphylaxis. Furthermore, we propose a mechanism
for its regulation, through glutamatergic auto-feedback of histamine-associated
mGluR7-expressing neurons. Future studies
should investigate whether individuals susceptible to anaphylactic
shock, or allergens, carry defects in this mechanistic chain
of events. Further, the development of mGluR7 agonists may
provide possibilities to prevent this life-threatening condition. and for MCAS OR SM

Interesting.  Thanks, Peter

Wonder if it was from too many mast cells coming to the site of the injury and releasing mediators locally.