Hi,

Unfortunately, the only way we know if something will cause a reaction in us, it to try it.  You may be fine, or not... You could try a tiny portion of it first and see how you do with it. It is not supposed to cause as many reactions as the real opiates.

You could try acupressure points--it works for me everytime I get a headache, but I don't have migraines, so not sure if it would totally help you.  I press above and on my eyebrows for several minutes--you will be able to feel the spot. There are other spots--you an Google it. Also, acupuncture can help, if that is a possiblity for you.  Then, you wouldn't have to take more drugs:)  It works WONDERS for me with everything. I'm so sorry you are feeling so crummy--Sarah

Tramadol is often prescribed for pain in mast cell patients, because it is less likely to cause degranulation than some other pain meds.  I felt a little strange on it, but didn't degranulate. You can also pre-medicate before you take it to minimize any symptoms from it.