I do not know the answer to your exact question concerning the amount of compounded estradiol that it would take to cause a reaction in you, but I have some thoughts.

Minute amounts of peanut butter can cause death in some people.

Airborne pollin is not necessarily easily visible, yet it causes allergic reaction in some individuals. In addition, the barely visible dust particle can cause a reaction.

My logic is telling me that it may not take much.  I can think of three factors that can influence your reaction:  the strength of the offender, your sensitivity to it, any other substance that is in your body along with the offender that can exacerbate or intensify the effect of the original substance.

In your case, it may be the estradiol, what it was compounded with, or another entirely unrelated change in your environment.

Hi Kallie,

Estrogen is a known MC degranulator because the MC has receptors for it..  I doubt you have an allergy to it.

Too often we, and even our doctors, confuse what is a true IgE mediated allergy versus what is a direct MC driven reaction.  MCs are directly triggered by female hormones - this is normal activity.  Why? because this is what menstruation is all about.  You can´t have the heparin released without the female hormones triggering the MC.  These hormones trigger through the receptors for these hormones.  This is why many masto patients have reactions which get worse at that time of the month.  

Yet what has this to do with peanuts?  

Well, masto patients can indeed have real allergies and it´s worth asking an allergist do a blood panel for IgE antibodies so that you can determine what are true allergies and thsu avoid them.  Also immuno anti-body therapy works to help reduce the sensitivity to those IgE mediated allergies and thus make it harder to react to so many things.  

Kallie I would suggest asking your doctor to speak with Dr. Castells about the hormone issues.  She knows how to deal with this beautifully.  I would also suggest that you send a PM to Starflower because she was put on an elimination diet by Dr. Castells which helped her greatly to the hormonal reacting.  

I hope this helps!

Lisa