Zyrtec should have minimal to no effect on tryptase. Antihistamines are very weak mast cell stabilizers.
Tick bite induced allergy would also trigger mast cells. Currently that would be called secondary mast cell activation disease.
After taking antibiotics did your symptoms return? Mast cells need some time to refill mediators. Antibiotics trigger mast cells. So it may be, that you got triggered hard and then the mast cells needed some time to refill and you felt better.
Quote:It is not clear why hydroxychloroquine (Plaquenil) is effective at treating autoimmune diseases. It is believed that hydroxychloroquine interferes with communication of cells in the immune system.
Quote:Does hydroxychloroquine (Plaquenil) help you?
With MCAD you have to differentiate between idiopathic and secondary mast cell activation.
Autoimmune diseases, allergies, virus infections can trigger mast cells (secondary).
In MCAS there are mast cells which behave differently, they are very easily triggerd and by lots of common substances.
You can investigate it yourself by writing down what triggers you and doing a elimination diet.
Why this mast cells are so easily triggerd is unknown. It may be that there are mutations which are caused by virus infections.
Quote:http://www.croh-online.com/article/S1040-8428%2814%2900149-8/abstractThus until whole genome sequencing becomes routine, the term “undetermined clonality” may be more accurate. The conclusion that MCAS is due to a large extent to mutations in mast cells is strongly supported by the findings of a recent systematic study of familial clustering of MCAS