Mast Cell Disorders Forum - Video by Dr. Castells a must watch very informative

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Video by Dr. Castells a must watch very informative (Read 6499 times)

CrystalG Tutor Offline If you are at peace, you are living in the present Posts: 63 Maine	Video by Dr. Castells a must watch very informative 09/30/14 at 10:22:12 This is a link to a video by Dr. Castells. It does a great job at detailing effective treatment for MCAS. http://www.youtube.com/watch?v=JdbkviPUmg4
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Futurehope Mentor Offline Posts: 357 Clermont, Florida	Re: Video by Dr. Castells a must watch very informative Reply #1 - 10/02/14 at 01:45:34 Thanks for the video. But I do not understand mastocytosis vs monoclonal mast cell disorders vs MCAS?! Is there a definition or write up of the above on this site? Maybe I could understand better which one I have. TIA
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CrystalG

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If you are at peace, you
are living in the present

Posts: 63
Maine

Re: Video by Dr. Castells a must watch very informative
Reply #2 - 10/03/14 at 01:48:32

Futurehope I do not know a lot of information about this either and was not able to find any write up as I found this video on Youtube. I think the monoclonal mast cell activation is the one where you have the genetic mutation and the non clonal mast cell activation is not the genetic mutation, but not sure how this differs from Mastocytosis. Sorry I couldn't be more helpful.

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Spartako

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Re: Video by Dr. Castells a must watch very informative
Reply #3 - 10/03/14 at 07:13:57

http://www.clinicaltherapeutics.com/article/S0149-2918%2813%2900171-9/pdf
Quote:

MMAS is diagnosed based on the presence of clonal
mast cells in the bone marrow specimens of patients
who do not meet the diagnostic criteria of SM (fulfill-
ing only 1 or 2 minor criteria).
Clonality is usually revealed by the presence of the D816V KIT
mutation and aberrant expression of CD25 on bone marrow
mast cells.

Dr. Molderings argues in his recent paper that all forms of MCAD are from mutations so they are all clonal.
http://www.croh-online.com/article/S1040-8428%2814%2900149-8/fulltext

Quote:

Recent studies, in particular those involving next generation sequencing analyses of advanced systemic mastocytosis, have revealed mutations in additional genes. The respective genes encode proteins for various signaling pathways, epigenetic regulators, the RNA splicing machinery, and transcription factors.

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Spartako Tutor Offline I Love YaBB 2! Posts: 58	Re: Video by Dr. Castells a must watch very informative Reply #4 - 10/03/14 at 08:24:26 If you want more insight I suggest searching for scientific papers on http://www.ncbi.nlm.nih.gov/pubmed/ http://scholar.google.com/ You also can make google alerts to keywords on google scholar so they send you an email if something new comes out.
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CrystalG Tutor Offline If you are at peace, you are living in the present Posts: 63 Maine	Re: Video by Dr. Castells a must watch very informative Reply #5 - 10/03/14 at 11:51:15 Thank you Spartako for the information! I will look into this.
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Futurehope Mentor Offline Posts: 357 Clermont, Florida	Re: Video by Dr. Castells a must watch very informative Reply #6 - 10/04/14 at 03:33:13 The following definitions helped me: http://www.clinicaltherapeutics.com/article/S0149-2918(13)00171-9/pdf
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CrystalG Tutor Offline If you are at peace, you are living in the present Posts: 63 Maine	Re: Video by Dr. Castells a must watch very informative Reply #7 - 10/05/14 at 04:56:18 Thank you futurehope this looks like a great article and recent.
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