I had blood work run recently and found that I have TSH at 7.5 and T4 at .71 - in other words I have hypothyroidism. I was given a prescription for Synthroid, but had to have the generic Levothyroxine given because of the fillers/inactive ingredients in Synthroid. I react to all dyes and many inactive ingredients.

I didn't tolerate the Levothyroxine - bad stomach aches. My mast cell disorder is mainly centered in my gut with high mast cell counts still despite being on a mast cell cocktail of drugs.

I tried the compounded T4 with no fillers and still didn't tolerate it. My endocrinologist then tried compounded T3 and then dessicated porcine T3/T4 compounded - I couldn't tolerate any of these either. I got a burning mouth symptom, canker sores appeared the next day, and my gut has been reacting for a week.

Has anyone had this issue of reacting to the actual hormone itself? I'm not reacting to the fillers or the capsule - I've had this same compounding pharmacy use the same capsule and filler for my Ketotifen, which I tolerate fine. So it's got to be that I'm reacting to the drug itself.

The doc doesn't know what to do with me! Help.

Nicole, do you have a mast cell doctor? If so, you need to have your 2 doctors help so they can work together to figure out how to treat the hypothyroidism.