Hi Vinnie,

Welcome! Although you have been a member here for over a year, you haven't posted before today. So, we don't know your background and it will be difficult to make suggestions without knowing about you. Why don't you write us a post describing what your medical condition is, what type symptoms you have, and what your questions are for us? I am sure that you will receive plenty of answers then!

Congratulations, by the way, on being Cancer free!!!!!!

No IgE alergies that I know of! Tryptase was elevated when tested, but don't know by how much!
My problems started really when I got breast cancer. The treatment I had was 'full on' so to speak! (this was 7 years ago,by the way). The chemo lasted 9 months,& was followed by 18 months or so of Tamoxifen, then because that made my bones ache so much,I was put on monthly Fasladex injections(these stopped in Jan this year), & for 1 year, Zoladex(this was to shrink my overies to next to non!!) Oh, I forgot to say that I had 18 radiotherapy sessions after the chemo. This seemed to lead to my thyroid gland finally giving up!
 Anyway, all through my treatment I found it hard-very tiring & debilitating. Eg, when I was having chemo,I'd have it on a tues & by the Sat, my bloods would be so low(neutrophils infact nil!), soI would find myself in hospita!  Anyway, all that left me exhausted for months after. To be honest,it still not good.
 So, go forward 4-5yrs( these skin type problems started 2-3 years ago) If only it was just itchy skin! I started to get bad headaches, stomach pains, severe bouts of diarrhea & vomiting(bad enough to be hospitalised),aching joints, chronic fatigue & skin that, especialy, when touched would flare up puce colour, itch like nothing I'd ever experienced before! Firstly I was seen by a GP, who takes a special interest in dermatology. He prescribed Dermacool(aquias cream with menthol crystal in it, & low dose antihistamine. It got worse, & my asthma started to deteriorate, so was sent to the chest clinic, where my meds were tweeked big time! He thought the things were probably related, & he was the one that put me on the Singulair. He also suggested that I be seen by a consultant dermatologist. He did do some skin patch tests to see if I had any allergies, but that only showed tree pollen.
Meanwhile, all these things are not improving! So, after a wait that seemed forever, I saw a Dermatologist, who put me on the Fenofexadine 180mg, cetirazine 10mg x 3 daily & Ranitidine 150mg twice a day. I saw her at my local hospital, & because she'd never seen whatever it was so bad, she sent me to Manchester to see Dr Marsland, who said that the urticaria( with accompanying severe dermagraphism)really was bad. He did some blood tests(?) and  a 24hr urine collection(is this how they found that the tryptase levels).
He said to try uvb light(didn't work)PUVA( had 2 goes at it & no,it didn't work,but I did get a nice skin colour!!!) & now I have started to take a drug called Dapsone. Its a sulfonamide type antibiotic that was/is used in the treatment of leprosy! My starting dose is 50mg increasing upto between 200-300mg. It works by preventing the mast cells from disgorging there load so to speak. I still struggle with all  other symptoms at present on 7 off. I've asked the question whether this is a mast cell disease & the answer is vague! Obviously my mast cells are very over active & drop there load at the drop of a hat!!!
Some of the triggers are alchohol, heat, certain smoked cheeses(!). The heat trigger is a bit unfortunate for me,as ever since my chemo, I've suffered drenching sweats day & night! & it doesn't matter what the weather is either as far as these sweats are concerned, evan at minus 10 I looked like I'd just got out of the bath- fully clothed mind-!
Anyway, I think this is enough to be going on with!!!
ps. I forgot to mention the Nasonex steroid nose spray!!

sorry been off site for so long, just not feeling very well. The answer for the morphine is that I came off it(under strict medical super', so to speak!) & the only thing that happened was an increase(BIG time)in pain! So at least I can take it now & now that its not that!!!
 I've now started the dapsone, & to be honest. not a lot is happening! Other than some strange liver enzyme stuff!!! But only been taking it for 3 wks.
 Nobodies said anything about biopsing(?) my urticaria., they just appear to be treating the symptoms & hoping that it goes away!!! I have had some very basic tests,but because they've come back either negative or ?, & I think because I do have quite a complicated medical history, as I say, they treating the effect & maybe not the cause!!
 Also I'm based in the UK, & you know although the NHS is fantastic, it does sometimes take time & effort to get things sorted1
 Thanx for your thoughts & help.