OMG for me it has totally improved my symptoms just geting on the right dose, I was one of the people that saw Dr. Blair Grubb wonderful man wonderful Dr. but it was the mast cell meds that helped me not the pots medication. I still take atenlol 12.5mg twice a day I just can't seem too get off of that dose, I do get tachy back not like I used too be. I also have a clondine patch .1mg that made  a big difference in my BP it does sometimes get high and if I am having a bad mast cell day my pots comes back in full force if I am having a day where my mast cells are behaving the pots basically dissappears even the syncope feeling. IT took me a long time too tweek my meds, but pots is not my main problem anymore, its more the other symptoms getting them under control like the diarrhea and bloating and such and even that is better but I think its b/c I am on a good combination for me, I was set off the the other day go figure from some caulking they used while they were fixing my shower I got the tremors which I have not had for months and the tachy but once I left my house and took extra meds i was much better so yes I believe the pots will at least be minimized if you get the mcad under control even Dr. Grubb told me that he said it would not matter if he put me on a large amount of beta blocker I would prob get sicker its the mast cells that are making me have the pots. OK good luck and I hope the pots get better that is the worst feeling I had it for basically two years went all over now I doubt I would ever fail the tilt table test in fact unless I was flaring I doubt I would even get tachy maybe just a little

Hi Futurehope,
I actually had a sudden onset of POTS, more of a hyper type which some doctors dismissed since my blood pressure was going up instead of down, but sometimes it would drop.  So it was confusing for doctors.  I was told I had a different form of POTS while in the hospital but had so many other health issues at the time, that by the time I got to a doctor for it, 4 years later, it had resolved but turned into autonomic neuropathy and orthostatic intolerance.  At the time when I had POTS, I had a severe fungal lung infection which triggered the POTS I think.  But also had toxic thyroid and thyroid cancer, but once that was resolved, that's when the POTS resolved, but the orthostatic intolerance was very difficult still.  I couldn't grocery shop or barely stand up without passing out. And eating at the table was out.  Anything that required me to be in an upright position for very long was out.  I'm sorry you are dealing with this. It was a terrible time in my life.  I'm not saying it can go away, but it is possible in some cases.  But for me I think the mast cell situation, is possibly a huge contributor.  WE are still out on the fence with the mast cell diagnosis.  Dr. Castells is rechecking my files and I have been diagnosed by two doctors, so it looks very likely. Hopefully you can get this all straightened out.  Hang in there.

My daughter has both POTS/MCAD. We also started with Dr Grubb. She takes midodrine, mestinon, florinef. She improved greatly on those but still was having lots flushing and abdominal issues. Lots of new onset allergies. She also took both H1 and H2 antihistamines. She was able to go to college and made it to grad school. (she had been homebound for 5 yrs) She now lives in Boston.
  I started pursuing the MCAS stuff and she saw Dr Castelle. Gastrocrom has helped her alot - no side effects for her and greatly decreased her fatigue. She has been able to cut back on most of the POTs drugs and mainly takes them in the morning now. She has even started running.