I have been depressed off and on over the last few months.  I have noticed that the depression is worse after I have an Mast cell issue.  I have read where this is all related. If I would never have a mast cell issue I would be emotionally stable...but as you know we are like pinball machines being set off by so many crazy things.  So I believe I NEED an antidepressant.
If any one is on anything that is helping you please let me know.  I am getting tired of all the sad days and tears.
I have tried Prozac-swells my throat
wellburtin-swells my throat
effexor- makes my joints and bones hurt

I have read a little about doxepin and how it is an antidepressant and an antihistamine.  Does any one take this?  How much? and does it help.
Thank you for your help-Pam

Just wanted to add that ranitidine and famotidine, Zantac and Pepcid, two histamine blockers, make me depressed.  I thought I'd mention this in case you were not aware that medications can cause this side effect.  Also, singulair can affect moods.

Well I have been on Cymbalta for a couple of years now.  I was never clinically depressed but having a chronic illness (as my doc explained) depresses your system, if that makes sense.  Anyway I am on it (Cymbalta 60 mgs a day) and it really helps with some of the muscular skeletal pain that we masto's suffer from.  I have had no side effects from it.  I actually stopped taking it for a few months and the pain was constant in my bones so I will never go off it again.

Because I cannot tolerate antidepressants, I have had to take supplements.  I found 5-HTP and the amino acids tyrosine and DLPA helpful.  I also was helped for about year by taking St. John's Wort until I started to react to that herb, too.

I am so sorry you have too have this horrible part of this disease. I too suffered for about  a year I thought I was going too really lose It I thought for sure I was going crazy crying all the time for no reason well for a good reason I felt horrible. But, for me who never cried except at the birth of my beautiful children it was a shocker for my whole family my husband wanted too commit me too the hospital psych unit. So first you are not alone this is not unusual for this disease. Again I want too reiterat, per my Dr you have mast cell receptors in your brain causing you too react like this. Dr. Afrin had me go on around the clock ativan at first I thought this is never going too work I am going too be a druggy and walk around drugged all the time not so, I am so happy I listened too him I have a tendancy too want too treat myself since I am in the medical field also and tend too want too research and not take too many drugs my life has changed though I have this disease and now I am treating the symptoms. I started on a very low dose now I am up too about 3mg a day of course well spaced out it has changed my whole life, I also take atarax only at night 25mg. I can tell you personally if it were not for Dr. Afrin's advice on this I would have gone over the edge literally. I tried doxipen OMG I had severe tachycardia from it and my head , was like I was so dizzy it was not funny. I react too everything even the ativan so I started slow and worked up too what I am on now most of it I take at night but during the day I do take about .25mg sometimes even less if I am having a good day about three times a day. I tried prozac another one on my do not take lists made me feel so sick I bascially could not move for most of the day. I even saw a psych MD of course this was b/f I knew I had this disease all I knew was I was going crazy so please if u can email Dr. Afrin tell him about what is going on with you, and have your dr contact him about this. Ok I so hope you feel better BUT again you are not depressed I know this is hard too hear its the disease that is making you feel like this I  know b/c I have been there , I still get very small bouts of depression but it goes away so fast I can tell you I have not had one crying spell for about two months now since I started this ok so sorry for my long rant

Goldielove,
Thanks for telling me about yourself.  I didn't have a clue why I couldn't stop cryinging. We have had a stressfull few weeks.  The company my husband worked for just didn't pay some of the employees due to having no funds.  My husband finally got a check a week late and before he could cash it the funds were removed from the account.  I was flipping out because I can bearly leave the house let alone get a job.  So I know that stress was working on my mast cells.  But the crying started and I just felt such a deep down sadness that I couldnt shake. I think I cried for two days.  My husband had and interview and a job offer in the same day.  I am on the upswing I think, cause I'm not crying like I was and I feel like things will get better.  I will try to have my doc. contact Dr. Afrin.  My specialist seems pretty with it but he doesnt want to treat my emotions which I guess if I think about it..he is an allergist/immunologist and has no reason to treat my emotions.  But like you said we have mast cells in our brain, creating problems!  He just needs to have DR. Afrin make that connection for him.

Thanks for your advice!
Pam