Title      Tryptase is not cleared by the kidneys into the urine.
Author(s)      Simon MR, Jan M, Yee J, Nori US, Hu J, Akin C, Schwartz LB
Institution      Allergy and Immunology Section, William Beaumont Hospital, Royal Oak, MI 48073, USA. mrsimonmd@sbcglobal.net
Source      Int Arch Allergy Immunol 2010; 152(1):28-31.
MeSH      Anaphylaxis
Humans
Kidney
Mastocytosis, Systemic
Tryptases
Abstract      Patients with chronic kidney disease have been reported to have increased concentrations of blood tryptase. Detection of tryptase in the urine of healthy subjects has been reported.The objective is to determine whether tryptase is indeed cleared by the kidneys.Blood and urine collections were performed in healthy and systemic mastocytosis subjects. Total and mature tryptase concentrations in blood and total tryptase concentrations in urine were determined.Total tryptase levels in urine were below the limit of detection in both healthy subjects and those with systemic mastocytosis, even after concentrating the urine 10-fold. Thus, both mature and protryptase levels in urine are <0.2 ng/ml.Tryptase is not cleared by the kidneys into the urine.
Language      eng
Pub Type(s)      Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
PubMed ID      19940502

http://www.unboundmedicine.com/medline/ebm/record/19940502/full_citation/Tryptas...