Of course ask your doctor first, but I found doxepin very helpful for sleep.  In addition to being sedating, it is both an H1 and H2 blocking drug.

Can you list exactly what meds you take and the doses? I have never heard of any mast cell people who actually experience insomnia from these meds. Since they all cause fatigue, it just doesn't make sense. Are you taking any meds for any other conditions? Perhaps it is one of those causing the problem.

All I know is prior too getting sick I used too sleep without any problems. Its seems the vistril 25mg that I was started on has started to help me but last night I guess my body was so tired I slept 12 hours , and I was really tired all day today. I can't win, I think it has something too do with the dysautonomia/ pots I have but both mast cell Dr's I saw told me when the mast cells quiet down I should be able too sleep better. I even tried half the vistril and i could not sleep so that is why I took the full dose. I take zantac 150 2x day, zrytec 5mg am 5mg 2pm and 10mg pm. Singular 10mg pm ( new drug for me) and Vistiril 25mg hour of sleep, and clonodine patch .1mg changed weekly and atenlol 25mg once a day actually I cut it in half and take 12.5mg twice a day, I have tried to stop the atenlol but my heart rate goes too fast. I also take Tramadol as needed for my headaches. Oh I also take ativan when I go too sleep its amazing now thinking about it I should be out with all the sedating meds I take I don't understand this. One more question that I have been meaning too ask, after I have a bad mast cell attack like today my face was really flushed and My BP went really high had a bad headache the one thing I notice is after this type of attack for about three hours I urinate at least every 15min and I mean urinate not drops anyone else get this after a bad attack?

i agree with Deb, all our drugs slow metabolism, but can understand anxiety causing sleep problem, i take couple valium with my zrytec & liquid benedryl & gastrocrom. tough not to sleep then. the problem is sometimes takes a little effort to wake in the morning & of course the
main thing I do is read before bedtime to try to get my mind off my chronic skin pain. also if wake in mid night take some more liquid benedryl & read a little works for me unless I have a big release in the night then all bets off.
mikev

I go through periods of insomnia- sometimes will last a few days, weeks or months, then will be ok for a while. I'm in the 'ok' phase right now, but a few months ago a naturopathic doctor told me to take melatonin, and it worked. I took 5mg about an hour before bed, and after about 6 weeks cut back to 3mg. I bought mine online, but I think you can get it at most grocery stores in the supplement section. I didn't experience any side effects from it, which I liked a lot. Check with your doctor first of course, but I was happy to finally find a more natural answer to my years of sleeping problems.