Hey guys, Im Tracey, 42 yr old female.   Its been a long 7 year journey to get a diagnosis of Ehlers Danlos Syndrome Type 3, POTS, Dsyautonomia, Reynauds, and CFS.  Im trying to understand since Mast Cell runs in the connective tissue arena if I have it or not.   If I do I believe its MCAD and that I may have triggers.  
I normally do NOT have itching, hives or rashes.  Mine presents more as fatigue, allergies, some digestive issues, and brain fog.   I even have light and noise sensitivity (which Im not sure that is related or not).

So far the cocktail Ive started recently is:
Allegra, Zantac, Zaditor, Nasalcrom, Singulair,Pataday, Asthma inhaler steriod - Alvesco.   I cant handle the Zrytec (makes me way too sleepy).  Im starting low on the Allegra and building up.  Zantac Im already up to 150 with hopes to go to 300.  My system due to POTS etc is sensitive to new meds so its a progression .   This is just my antihistamine regimen.   I have to take other meds for POTS/Dsyautonomia.

I contacted Dr Castells office this week and Im awaiting paperwork from her on which tests she may need.   It will be good to rule it in or out.   I really appreciate this forum and all of you sharing your experiences.  Very helpful.  Thank You.  Tracey

Lisa, can you tell us more about the study which is being proposed regarding EDSIII, POTS and Masto?  Who is steering that study and where and when?  

Dr. Afrin seems to agree with this line of thinking - that this trio is driven by an underlying problem with the mast cell.  What other doctors are thinking this?  

Thanks!  The number of us with these three diagnoses is growing daily.  It is exciting to think we are on the verge of some interesting developments!

Thanks Lisa!  I am on another forum with Sarah so I was aware of that study...just wanted to make sure I wasn't missing something    I was actually reading about Dr. Wilson tonight...sounds like he is doing some interesting stuff.    

Thanks for sharing all of your knowledge with the rest of us!  It sounds like you have really been through a lot and I appreciate your willingness to share what you've learned as you really have done a lot of research!