Anyone have experience with Xolair? I know it's been quite successful in controlling chronic urticaria and its mast cell-related symptoms in  an ongoing US-based trial.

Omalizumab Treatment of Systemic Mast Cell Activation Disease:
Experiences from Four Cases

Internal Medicine
Vol. 50 (2011) , No. 6 pp.611-615

Gerhard J. Molderings1), Martin Raithel2), Felix Kratz3), Marc Azemar3),
Britta Haenisch1), Sabrina Harzer1) and Jürgen Homann4)
1) Institute of Human Genetics, University Hospital of Bonn, Germany
2) Universitätsklinikum Erlangen, Medizinische Klinik, Germany
3) Tumor Biology Center, Germany
4) Evangelische Kliniken Bonn, Germany

Abstract

We report on the outcome of 4 patients with therapy-resistant systemic
mast cell activation disease (MCAD) treated with the anti-IgE monoclonal
antibody omalizumab in compassionate use.

Two patients achieved an impressive persistent clinical response to
treatment with omalizumab.

In the third patient symptoms gradually improved.

In the fourth patient omalizumab treatment had to be discontinued
due to intolerable mast cell mediator-induced symptoms.

In conclusion, omalizumab can lessen the intensity of the symptoms
of systemic MCAD.

Hence, omalizumab should be considered as a therapeutic option in
cases of systemic MCAD that are resistant to evidence-based therapy.

Key words:
systemic mastocytosis, omalizumab, tryptase

http://www.jstage.jst.go.jp/article/internalmedicine/50/6/50_611/_article
full article
http://www.jstage.jst.go.jp/article/internalmedicine/50/6/611/_pdf