Hi Everyone ,

My cholesterol has been high for a while . It went off the scale yesterday and I am awaiting a second lot of blood test results and may need to go to hospital today as it is very very high . total 24 . triglycerides 75 , yes you read correctly .

There is a connection emerging in literature between mast cell tryptase and cholesterol balance .  It has been found that tryptase , stops cells processing HDL . Leaving more in the circulation .

Reference :-
(Arterioscler Thromb Vasc Biol. 2002 Dec 1;22(12):2086-91.
Mast cell tryptase degrades HDL and blocks its function as an acceptor of cellular cholesterol.
Lee M, Sommerhoff CP, von Eckardstein A, Zettl F, Fritz H, Kovanen PT.  Wihuri Research Institute, Helsinki, Finland.


There has also been a literature review , which concluded that mast cell disease is a risk factor for high cholesterol .

Reference :-
Liver Int. 2009 Feb;29(2):181-6. Epub 2008 Jul 23.
New aspects of liver abnormalities as part of the systemic mast cell activation syndrome.
Alfter K, von Kügelgen I, Haenisch B, Frieling T, Hülsdonk A, Haars U, Rolfs A, Noe G, Kolck UW, Homann J, Molderings GJ.
Evangelische Kliniken, Waldkrankenhaus, Department for Internal Medicine, Bonn, Germany.


It has been known for a while that LDL degranualtes mast cells .

Mastocytosis is known to have high cholesterol as a symptom , but until now the cause has not been identified .

My immunology team do not want me to have stains , which are a common cholesterol treatment . Fibreates are another group. But i reacted to the capsules and corn flour .

I am diabetic , so my cholesterol is likely to be due to high sugars , which I need more insulin for , but I have been waiting for a specialist appointment , which is due next month .

But we are going into a bank holiday here , so hospital is always looming . I haven't spent a bank holiday at home in 2 years .

If I go quiet then , you know I have gone in .

many hugs all

Josie