Hi Don ,
Regarding Angiodeama , taigo is correct in there being many causes . My derm / immuno , when looking for the cause in me , expained it falls into histamine based - IGe allergy , mastocytosis , mast cell activation , ( Atopy as taigo describes it )
autoimmune based - most commonly but not excusively :- hashimotos thryroidosis , autoimmune addisions ( adrenals ) , renal , lupus , and
Kinin based - HAE . for the femaile members with symptoms a 3rd type of HAE has been documented related to oestrogen ( 2006 ) so still new . The other thing to consider is that the C1 maybe normal but not working properly . This may be an important question for your family to ask your immuno .
H Pylori , bug found in the stomach which causes ulcers in the long term is a known trigger of HAE angiodeama . It is easily erdicated with antibiotics and a proton pump inhibitor for 6 weeks
Its called triple therapy .
Some random , rare causes are also known xxxxxxx In particular carciniod syndrome and pheaocryocythoma . But they have specific symptom groups . I don't know enough about you to comment further xxxxxxxxxxxxxxxxx They are unlikely with a family history which has not led to these diagnosies in the past
The test for carciniod in a chemical which is high level - 511HA ( urine 24hour collection ) ( 70 % ) and chromoatogranin A ( 100 % ) . Pheaocryocythoma is a test of epinepherine and nor epinepherine levels ( urine 24 hr collection )
Hugs and lots of anti histamines
Josie xxxxxxxxxxxxxxxxxx