Mast Cell Disorders Forum

Mast Cell Disorders Forum
http://mastcelldisorders.wallack.us/yabb/YaBB.pl General Mast Cell Disorders Discussion >> General Mast Cell Disorder Discussion >> about time http://mastcelldisorders.wallack.us/yabb/YaBB.pl?num=1451783595 Message started by peter on 01/02/16 at 13:13:15

Title: about time
Post by peter on 01/02/16 at 13:13:15

Identification of a Neuronal Receptor Controlling
Anaphylaxis

Title: Re: about time
Post by peter on 01/02/16 at 13:22:30

http://www.cell.com/cell-reports/pdf/S2211-1247(15)01457-6.pdf

Title: Re: about time
Post by peter on 01/02/16 at 13:35:21

Previously, anaphylaxis has been regarded as a result of an
over-active or defective immune system. We now present data
suggesting that dysfunctional regulation of primary afferents
can cause anaphylaxis. Furthermore, we propose a mechanism
for its regulation, through glutamatergic auto-feedback of histamine-associated
mGluR7-expressing neurons. Future studies
should investigate whether individuals susceptible to anaphylactic
shock, or allergens, carry defects in this mechanistic chain
of events. Further, the development of mGluR7 agonists may
provide possibilities to prevent this life-threatening condition. and for MCAS OR SM

Title: Re: about time
Post by peter on 01/03/16 at 09:27:38

This is how the signals of anllagic reaction gos to the brain instead of the body as in bypassing the controler

Title: Re: about time
Post by Joan on 01/10/16 at 18:59:16

Interesting. Thanks, Peter

Title: Re: about time
Post by peter on 01/11/16 at 09:55:43

one part iv not been able to workout the day after shock from a sting my knee went red and swelled up so the venom was still in there but only a local reaction strange

Title: Re: about time
Post by Joan on 01/11/16 at 14:54:28

Wonder if it was from too many mast cells coming to the site of the injury and releasing mediators locally.

Title: Re: about time
Post by peter on 01/11/16 at 16:13:34

i guess that could be it a tinny injury though the whole knee went red and swelled up