Mast Cell Disorders Forum

Mast Cell Disorders Forum
http://mastcelldisorders.wallack.us/yabb/YaBB.pl General Mast Cell Disorders Discussion >> General Mast Cell Disorder Discussion >> Video by Dr. Castells a must watch very informative http://mastcelldisorders.wallack.us/yabb/YaBB.pl?num=1412112132 Message started by CrystalG on 09/30/14 at 10:22:12

Title: Video by Dr. Castells a must watch very informative
Post by CrystalG on 09/30/14 at 10:22:12

This is a link to a video by Dr. Castells. It does a great job at detailing effective treatment for MCAS.

http://www.youtube.com/watch?v=JdbkviPUmg4

Title: Re: Video by Dr. Castells a must watch very informative
Post by Futurehope on 10/02/14 at 01:45:34

Thanks for the video. But I do not understand mastocytosis vs monoclonal mast cell disorders vs MCAS?!

Is there a definition or write up of the above on this site? Maybe I could understand better which one I have. TIA

Title: Re: Video by Dr. Castells a must watch very informative
Post by CrystalG on 10/03/14 at 01:48:32

Futurehope I do not know a lot of information about this either and was not able to find any write up as I found this video on Youtube. I think the monoclonal mast cell activation is the one where you have the genetic mutation and the non clonal mast cell activation is not the genetic mutation, but not sure how this differs from Mastocytosis. Sorry I couldn't be more helpful.

Title: Re: Video by Dr. Castells a must watch very informative
Post by Spartako on 10/03/14 at 07:13:57

http://www.clinicaltherapeutics.com/article/S0149-2918%2813%2900171-9/pdf

Quote:

MMAS is diagnosed based on the presence of clonal
mast cells in the bone marrow specimens of patients
who do not meet the diagnostic criteria of SM (fulfill-
ing only 1 or 2 minor criteria).
Clonality is usually revealed by the presence of the D816V KIT
mutation and aberrant expression of CD25 on bone marrow
mast cells.

Dr. Molderings argues in his recent paper that all forms of MCAD are from mutations so they are all clonal.
http://www.croh-online.com/article/S1040-8428%2814%2900149-8/fulltext

Quote:

Recent studies, in particular those involving next generation sequencing analyses of advanced systemic mastocytosis, have revealed mutations in additional genes. The respective genes encode proteins for various signaling pathways, epigenetic regulators, the RNA splicing machinery, and transcription factors.

Title: Re: Video by Dr. Castells a must watch very informative
Post by Spartako on 10/03/14 at 08:24:26

If you want more insight I suggest searching for scientific papers on
http://www.ncbi.nlm.nih.gov/pubmed/
http://scholar.google.com/

You also can make google alerts to keywords on google scholar so they send you an email if something new comes out.

Title: Re: Video by Dr. Castells a must watch very informative
Post by CrystalG on 10/03/14 at 11:51:15

Thank you Spartako for the information! I will look into this.

Title: Re: Video by Dr. Castells a must watch very informative
Post by Futurehope on 10/04/14 at 03:33:13

The following definitions helped me:

http://www.clinicaltherapeutics.com/article/S0149-2918(13)00171-9/pdf

Title: Re: Video by Dr. Castells a must watch very informative
Post by CrystalG on 10/05/14 at 04:56:18

Thank you futurehope this looks like a great article and recent.