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http://mastcelldisorders.wallack.us/yabb/YaBB.pl General Mast Cell Disorders Discussion >> General Mast Cell Disorder Discussion >> What is Difference between PG D2 and 11 Beta-Prostaglandin F2 Alpha? http://mastcelldisorders.wallack.us/yabb/YaBB.pl?num=1400441795 Message started by Ladybug on 05/18/14 at 08:36:35

Title: What is Difference between PG D2 and 11 Beta-Prostaglandin F2 Alpha?
Post by Ladybug on 05/18/14 at 08:36:35

I'm trying to figure out some of the results of my 24-hour urine specimen lab results taken on a normal day and frozen at home and transport, chilled at lab.

I have a high 11 Beta-Prostaglandin F2 Alpha AND PG D2, but a normal N-Methylhistamine.

I've found very little on both of the ones that I was high on and hope that someone here might have some info.

Thank you!

Title: Re: What is Difference between PG D2 and 11 Beta-Prostaglandin F2 Alpha?
Post by Lisa on 05/21/14 at 16:58:38

11 Beta-Prostaglandin F2 Alpha is a metabolite of PGD2. Having elevated levels of either indicates MC activation and would be considered diagnostic for MCAS.

histamines and methyl-histamines is the same thing, the methyl-histamines is the metabolite of histamines. Not having them be elevated isn't an issue as long as the PGD2 is elevated. The criteria for MCAS is having a mediator elevated and so having normal trytpase too doesn't rule out a MC disorder. In fact in a video I saw of Dr. Castells she said that even in mastocytosis they are recognizing that at least 20% of the SM patients have normal tryptase and they are beginning to adjust the criteria to recognize this!

I hope this helps!

Lisa

Title: Re: What is Difference between PG D2 and 11 Beta-Prostaglandin F2 Alpha?
Post by Ladybug on 05/26/14 at 10:19:17

Yes, this does help, Lisa. Thank you, very much!