Mast Cell Disorders Forum

Mast Cell Disorders Forum
http://mastcelldisorders.wallack.us/yabb/YaBB.pl General Mast Cell Disorders Discussion >> Specific Mast Cell Conditions and Those that Mimic Them >> Study: H2 blockers effective at treating schizophrenia http://mastcelldisorders.wallack.us/yabb/YaBB.pl?num=1394367321 Message started by larken on 03/09/14 at 00:15:21

Title: Study: H2 blockers effective at treating schizophrenia
Post by larken on 03/09/14 at 00:15:21

I have MCAS with a strong mood component and my brother has schizophrenia. I wanted to post this for anyone else who may suffer from mood symptoms or have a family member with mental illness.

I have for a long time suspected that mast cells have something to do with his metal illness--in part because he had terrible allergies and other sensitivities as a child that he (presumably) outgrew. Also, both his illness and my MCAS started when we were the same age -- 23. We are now in our 40s. My mood symptoms directly correlate with my other systemic symptoms, so I know I am not suffering from both MCAS and a mood disorder.

My brother has not had much success with traditional anti-psychotic meds.

This led me to do some research on the connections between mast cells and mental illness. I have been in touch with one of the authors of this study:

http://www.psychcongress.com/article/antihistamine-decreases-schizophrenia-symptoms-12516

The study found that H2 blockers reduced symptoms.

The lead author cautioned that this is not a treatment option that is immediately available, but may be in a few years after additional studies.

He was excited to hear about this mast cell angle when I contacted him and said that as far as he knew, the connection between mast cells generally and schizophrenia has not been studied. I encouraged him to pursue it!

Title: Re: Study: H2 blockers effective at treating schizophrenia
Post by Lisa on 05/15/14 at 11:03:50

A very enlightening study, Larken. Thank you!!!!!

Lisa

Title: Re: Study: H2 blockers effective at treating schizophrenia
Post by Bruce Hart on 10/29/14 at 18:01:47

Great work larken. I'm glad you informed that researcher of MCAD. :)

I've seen another study with another H2 antihistamine improving treatment resistant schizophrenia, but this one you post is a much better study.