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http://mastcelldisorders.wallack.us/yabb/YaBB.pl General Mast Cell Disorders Discussion >> Medicines >> I think I just flunked Chromolyn 101 :( http://mastcelldisorders.wallack.us/yabb/YaBB.pl?num=1381709654 Message started by zippy890 on 10/13/13 at 13:14:14

Title: I think I just flunked Chromolyn 101 :(
Post by zippy890 on 10/13/13 at 13:14:14

I started low and slow on pure Chromolyn powder, 100mg/day, dissolved in warm water. No gut upset, just a little more tired. I did this for 3 weeks, and noticed I seemed to be getting more reactive, and my periph. neuropathy was getting worse. I thought it would pass. So, I bumped up to 200mg/ day in a split dose. That when things went off the rails. I got very tired. My skin itched horribly, plus many other symptoms. I stood it for one week, then I just couldn't take it any longer. So I quit. In 3 days, I felt 100% better.

Now, I have failed out on Ketotifen, and Chromolyn !

I have only two meds. after all this. Allegra and Doxepin. And I can only take a "certain" amount of those, or things go bad for me.

I am still undermedicated.

Any suggestions from those more experienced than me ? <s>

Todd in Tenn.

Title: Re: I think I just flunked Chromolyn 101 :(
Post by Spartako on 10/13/13 at 18:25:45

Are you intolerant to salicylates? Because Chromolyn has structural similarities to salicylic acid and because of that some also react to Chromolyn.

Title: Re: I think I just flunked Chromolyn 101 :(
Post by zippy890 on 10/14/13 at 13:03:54

Yes, I believe I am reactive to salicylates. Every time I try to take an aspirin, it bothers me really badly.

What to do ? (:-.

Title: Re: I think I just flunked Chromolyn 101 :(
Post by brigitte on 02/08/14 at 11:38:08

I had no idea cromolyn shared properties with salicylates. Is this true? If it is, it would explain why it makes me so sick. Ugh.
Does singulair share any salicylate properties?

Title: Re: I think I just flunked Chromolyn 101 :(
Post by Spartako on 02/08/14 at 17:27:40

I react to salicylates in food and aspirin but have no problems with my singulair brand.

Title: Re: I think I just flunked Chromolyn 101 :(
Post by Spartako on 02/08/14 at 17:35:24

I have not much idea about chemistry but the aspirin molecule and cromoglicic acid have some strong similaritys at one end.
Montelukast/Singulair is much more complex but it also has one end with OH-=O Atoms. Maybe this is what triggers mast cells?
Anyone here who understands more of chemistry?

http://en.wikipedia.org/wiki/Salicylate_sensitivity
http://en.wikipedia.org/wiki/Montelukast
http://en.wikipedia.org/wiki/Aspirin

Title: Re: I think I just flunked Chromolyn 101 :(
Post by mountain girl on 05/15/14 at 01:04:40

Zippy..have you tried Quercetin? There are a few threads on it you can read. Dr. Theo is a mast cell expert. He sells a formulation of Quercetin for mast cell patients that are very reactive. I do not take quercetin, but have heard some good things about it.

http://algonot.com/neuroprotek.php

http://www.mastcellmaster.com/

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0033805