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New Mast Cell Research, Studies, and Trials >> New Mast Cell Research, Studies, and Trials >> Role of mast cells in the pathogenesis of polymyositis http://mastcelldisorders.wallack.us/yabb/YaBB.pl?num=1339739775 Message started by peter on 06/14/12 at 18:56:15 |
Title: Role of mast cells in the pathogenesis of polymyositis Post by peter on 06/14/12 at 18:56:15 http://eng.ryumachi-jp.com/library/Downloads/mr_supple_all_2012.pdf Role of mast cells in the pathogenesis of polymyositis Kotaro Suzuki, Masaya Yokota, Hiroshi Nakajima Department of Allergy and Clinical Immunology, Chiba University Hospital Conflict of interest: None Mast cells have long been recognized as the major effector cells in allergic diseases such as asthma, allergic rhinitis, and atopic dermatitis. In addition, recent studies have revealed a new role of mast cells in the pathogenesis of autoimmune disease models including autoantibody-induced arthritis, experimental autoimmune encephalomyelitis, and insulin-dependent diabetes mellitus. While mast cells are located in skeletal muscle, their roles in the pathogenesis of autoimmune skeletal muscle diseases have not been clarified. Recently, a murine model of polymyositis, namely C protein-induced myositis (CIM), has been established by Sugihara et al. CIM has been shown to exhibit similar pathological features to those found in human polymyositis including a massive infiltration of CD8+ T cells and macrophages in the endomysium of skeletal muscles. However, the role of mast cells in the development of CIM remains unknown. To address this issue, we first examined the incidence and severity of CIM in mast cell-deficient WBB6F1-KitW/KitWv mice (W/Wv mice). We found that the incidence and histological scores of CIM were significantly reduced in W/Wv mice as compared with those in wild-type (WT) mice. In addition, reconstitution of mast cells in W/Wv mice with bone marrow-derived mast cells (BMMCs) restored the incidence and histological scores of CIM. These results indicate that mast cells play critical roles in the development of CIM and suggest that mast cells could be possible therapeutic targets in patients with polymyositis. |
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