Mast Cell Disorders Forum

Mast Cell Disorders Forum
http://mastcelldisorders.wallack.us/yabb/YaBB.pl General Mast Cell Disorders Discussion >> General Mast Cell Disorder Discussion >> Nicotinamide http://mastcelldisorders.wallack.us/yabb/YaBB.pl?num=1297100986 Message started by chaco on 02/07/11 at 05:49:46

Title: Nicotinamide
Post by chaco on 02/07/11 at 05:49:46

Has anyone tried this supplement as an alternative or adjuvant to prescription or OTC antihistamines?

I have read various articles claiming it inhibits mast cell degranulation and histamine release. I have some on hand, my son was taking it last year, but am a bit apprehensive about trying it since some B vitamins are a known trigger for me.

Anyone else have a problem w/B Vitamins? Either binding in the blood or reacting to supplementation?

Deb Mc

Title: Re: Nicotinamide
Post by Buster on 02/07/11 at 06:14:16

chaco wrote on 02/07/11 at 05:49:46:

Deb,

Thiamine (vitamin B1) is the only B vitamin that I have seen on "trigger avoidance" lists for people with mastocytosis or mast cell disease. I didn't find much in the medical literature regarding an association between thiamine and mast cell diseases.

However, I felt better on a bio-active form of thiamine when I took it in the past, but stopped taking it when I learned that it might make mast cell conditions worse. I think I will give it another trial to see what effect it has on me now.

Buster

Title: Re: Nicotinamide
Post by Starflower on 02/07/11 at 06:43:53

Niacin (B3) is also a known degranulator. I've stopped taking a multi-vitamin and have become very careful about supplements. IMO, while you're trying to figure out your triggers it's better to keep things as simple as possible.

Heather

Title: Re: Nicotinamide
Post by Buster on 02/07/11 at 06:52:06

Although the niacin form of vitamin B3 is a mast cell degranulator, the niacinamide (or nicotinamide) form is a mast cell stabilizer.

Title: Re: Nicotinamide
Post by chaco on 02/07/11 at 06:58:42

Nicotinamide is a form of B-3 or niacin that, unlike niacin, doesn't provoke flushing or help reduce cholesterol.

I have read that B-6, folic acid and B-12 all one way or another stimulate release or increase levels of histamine. I discontinued my B-12 shots and Co-enzymated B, folic acid and B-Complex supplementation after discovering that they were all individually triggering inflammation in my spine, increased muscle tension and myofascitis.

Deb Mc

Title: Re: Nicotinamide
Post by chaco on 02/07/11 at 07:10:54

Starflower wrote on 02/07/11 at 06:43:53:

Niacin perhaps. But from what I've read, nicotinamde has the opposite effect and inhibits mast cell release of histamine. Here's a link to one article that supports/discusses this.

http://www.springerlink.com/content/l164q45k73364727/

It's taken me nearly 30 years to identify all my known triggers. I was taking the B supplements and cobalamin injections at the recommendation of my orthopedic, prolotherapy and another doc, as I was severely deficient, and may still be. I imagine the deficiencies have something to do with whatever's causing my intolerance to B supplementation and everything else.

Deb Mc